pharmacophore


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pharmacophore

 [fahr´mah-ko-for″]
the group of atoms in the molecule of a drug responsible for the drug's action.

pharmacophore

(făr′mă-kō-for) [″ + phoros, bearing]
The three-dimensional shape of a molecule that makes it fit and activate cellular receptors.
References in periodicals archive ?
Release date- 19082019 - Philadelphia - Oncoceutics, Inc., announced that it has signed an exclusive, world-wide license for US patent #10,239,877, entitled 'Pharmacophore for trail induction', from The Scripps Research Institute ('Scripps'), covering the composition of matter of ONC201 as well as other molecules in the imipridone family.
(1) HDACIs consists of three defined structural parts of an ideal pharmacophore, i.e., (a) recognition cap group (b) hydrophobic linker, and (c) the zinc-binding group (Figure 2).
Zhang, Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generation, Eur.
One of the computational methods becoming increasingly popular to develop new drugs is relying on Pharmacophores. This method was utilized to develop pharmacophore models of Akt2 inhibitors and [beta]2-Adrenoceptor agonists.
Synthesis, activity, and pharmacophore development for isatin-[beta]-thiosemicarbazones with selective activity toward multidrug-resistant cells.
The potency and extensive applicability of the 1, 3-diazacyclopenta-2, 4-diene pharmacophore can be certified to its hydrogen bond donor-acceptor capability along with its elevated attraction for metals such as Zn, Fe and Mg reported by (Nagargoje et al., 2012).
Schiff bases: A versatile pharmacophore. Journal of Catalysts, 2013: 14.
The authors generated and validated a ligand-based pharmacophore model using a series of known anticancer compounds acting via CYP1A1.
In this work, we constructed the common feature pharmacophore model of PTP1B competitive inhibitors and estimated protein-ligand binding affinities by different docking protocols.
The most striking progress in medicinal chemistry have taken place in the last two decades, where the heterocyclic compounds have been recognized as important pharmacophore eliciting numerous biological activities [1].