pharmacogenomics

(redirected from Pharmacogenomic)
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phar·ma·co·ge·net·ics

(far'mă-kō-jĕ-net'iks),
The study of genetically determined variations in responses to drugs in humans or in laboratory organisms.
Synonym(s): pharmacogenomics

pharmacogenomics

(fär′mə-kō-jə-nō′mĭks)
n. (used with a sing. verb)
The study of inherited variations in genetic factors that influence a patient's metabolic response to a given drug, especially adverse side effects. Also called pharmacogenetics.

pharmacogenomics

The formal study of inherited genetic variations that dictate different drug responses. Pharmacogenomics explores the ways such variations can be used to predict responses to investigational products and plays an increasingly important role in drug discovery.

phar·ma·co·ge·net·ics

, pharmacogenomics (fahr'mă-kō-jĕ-net'iks, -nō'miks)
The study of genetically determined variations in responses to drugs in humans or in laboratory organisms.

pharmacogenomics

The recognition of the fact and significance of human genetic variability in relation to drug action and its application to medical treatment. Genetic variability affects drug absorption, distribution, metabolism and excretion. As a result, many drugs which work very well in some people work poorly in others. At present, the best doctors can do is to prescribe a drug and then wait and see how well the patient responds. Fuller knowledge of pharmacogenomics will, in the future, allow more reliable treatment and avoid expensive waste.

pharmacogenomics

analysis of the effects of GENOMICS on drug responses. This involves all the pharmacologically active genes, how they manifest their variations, how they interact to produce PHENOTYPES, and how these phenotypes affect drug responses. DNA MICROARRAYS/CHIPS should be useful in determining how genetic variation influences individual responses to a given drug or class of drugs. A major aim is to personalize drugs, by adapting them specifically to an individual's own genetic make-up, so that they will be fully efficacious with no side effects.
References in periodicals archive ?
The findings came from a secondary analysis of data from a trial with 3,037 acute coronary syndrome patients, who, for regulatory reasons, had to submit routine pharmacogenomic testing for clopidogrel-metabolizing status when they entered the study.
In conjunction, OneOme's RightMed pharmacogenomic test covers 22 genes, 340+ medications for more than 20 medical indications and it can be integrated into electronic medical records (EMRs).
Pharmacogenomic testing of a person provides key genetic information that can help in customizing therapy.
The Clinical Pharmacogenomics Implementation Consortium (CPIC), a shared project between Pharmacogenomics Knowledgebase (PharmGKB) and the Pharmacogenomics Research Network, has published peer-reviewed guidelines for drugs with pharmacogenomic data to help clinicians interpret genetic test results to optimize drug therapy.
C's psychotherapy, we used the pharmacogenomic results to guide medication treatment.
a company that provides a pharmacogenomic test, said in an interview.
CVS Caremark already provides pharmacogenomic intervention services in its specialty pharmacy business.
NVM also announced additional funding for leading biotechnology firm DxS to support their success in marketing and developing its pharmacogenomic service business.
Based in Melbourne, Australia, EpiTan holds a unique technology platform centred on its leading drug candidate Melanotan, one of a new breed of pharmacogenomic drugs.
On the basis of the trial results the companies may also pursue the development of pharmacogenomic tests to identify patients for whom a particular drug may be effective.
At the April 2003 US FDA Science Board meeting, Janet Woodcock, director of the FDA's Center for Drug Evaluation and Research, commented that greater analysis of pharmacogenomic data provides the potential to revolutionize drug development processes and lead to faster, more efficient production of less-toxic, higher-efficacy drags.
DNA-based pharmacogenomic tests are one of the great promises of genetics.