phage therapy


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phage therapy

the use of bacterial viruses (see VIRUS) to treat bacterial infections. Phage therapy offers a number of advantages over antibiotic therapy, for example phages offer high specificity for the target organism and have no effect on non-target organisms. Furthermore, they can mutate to overcome host resistance mutations. However, phages are often eliminated by the body's defence mechanisms (see IMMUNE SYSTEM) and this together with the production of endotoxins, which can result from lysis of bacteria by phages, has made such therapy less widely accepted. Nevertheless, the rapid emergence of multiple antibiotic-resistant bacteria has led to a renewed interest in the use of phages as therapeutic agents.
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'The Key Opinion Leader meeting that we hosted in June highlighted the potential for phage therapy to meet the urgent need for new treatments that address antibiotic resistance.
M2 PRESSWIRE-August 2, 2019-: Global Phage Therapy Market: Size, Trends & Forecasts (2019 Edition) Featuring Armata Pharmaceuticals, Intralytix, Adaptive Phage Therapeutics, Pherecydes Pharma, and Locus Biosciences
"Viruses like phage have been studied for 100 years but they are now receiving renewed interest because of the potential of using them for phage therapy," said Pogliano.
The medical team at Great Ormond Street Hospital, who were looking after Isabelle after a lung transplant for cystic fibrosis, turned to phage therapy as a last resort.
Utilising its advanced discovery and development capabilities in phage therapy, the company discovered phage that eradicate the pathogenic strains and is developing a customised phage cocktail as a therapeutic for PSC.
Alternative protections or incentives, such as trade secrecy, regulatory exclusivities, research support, alternative payment models, or some combination thereof, are likely necessary to spur phage therapy innovation.
This discovery could make phage therapy more attractive to drug companies since it would allow them to engineer specific phages that can kill on demand.
For the purpose of treating patients that are infected with antibiotic resistant bacterial pathogens, phages can be used as an alternative treatment (phage therapy).
More experimentally, phage therapy for multidrug-resistant Acinetobacter baumannii proved effective in a 68-year-old patient with necrotizing pancreatitis who continued to deteriorate over a 4-month period despite multiple courses of antibiotics and attempted drainage of a pancreatic pseudocyst.
The 22 contributions discuss the use of antimicrobials as growth promotants in the food animal industry, the growth of the organic production system, bacterial pathogens in compost, phage therapy approaches to reducing pathogen persistence, preharvest application of probiotics to farm animals, and molecular tools for studying food safety challenges.
Novel and emerging therapies targeting microbiome health, such as fecal transplants and phage therapy, are beginning to reshape the way doctors approach treating patients with certain diseases, especially those involving the gastrointestinal tract.
New approach to use phage therapy against Aeromonas hydrophila induced motile Aeromonas Septicemia in Nile Tilapia.