Peyronie's disease

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Peyronie's Disease



Peyronie's disease is a condition characterized by a bent penis.


The cause of Peyronie's disease is unknown and the disease is often difficult to treat. For some reason, a thick scar develops in the penis and bends it. Almost a third of patients with Peyronie's disease also have similar contracting scars on their hands, a disease called Dupuytren's contractures. Some cases are associated with diabetes, and others appear after prostate surgery. Because prostate surgery always requires a catheter in the bladder, there is some suspicion that catheters can cause the scarring. However, many cases of Peyronie's disease arise without any use of a catheter. There is also a congenital form of penile deviation, again with no known cause. Most of the scars are located in the mid-line, therefore most of the angulations are either up or down.

Causes and symptoms

Peyronie's disease occurs in about 1% of men, most of them between 45-60 years old. Although there is no good research data to back it up, the suspicion exists that Peyronie's disease is the result of injury. If not a catheter, then sudden, forceful bending during sexual intercourse could easily tear the supporting tissues and lead to scarring.
The symptom is bending of an erect penis, sometimes with pain. It often interferes with sexual intercourse. Erectile failure associated with the angulation often precedes it.


Attempts have been made to reduce the angulation with injections of cortisone-like drugs directly into the scar, but they are rarely successful. Surgery seems to be the better answer. After the scar is removed, plastic repair of the penis is attempted, often with a graft of tissue from somewhere else on the body. The Nesbit procedure is one of the more successful methods of doing this. The other surgical approach is to implant a penile prosthesis that overcomes the angulation mechanically. Results with these procedures are reported to be 60-80% satisfactory, including the return of orgasm.


Sometimes the condition disappears spontaneously. A careful look for other causes of impotence should be done before surgery.



Jordan, Gerald H., et al. "Surgery of the Penis and Urethra." In Campbell's Urology, edited by Patrick C. Walsh, et al. Philadelphia: W. B. Saunders Co., 1998.

Key terms

Catheter — A flexible tube placed into a body vessel or cavity.
Congenital — Present at birth.
Plastic surgery — The restoring and reshaping of the skin and its appendages to improve their function and appearance.
Prostate — A gland that surrounds the outlet to the male bladder.
Prosthesis — Artificial substitute for a body part.

Peyronie's disease

a self-limiting disease of the penis that causes hardening of the corpora cavernosa, resulting in painful chordee and penile curvature.

Peyronie's disease

Etymology: François de la Peyronie, French physician, 1678-1747
a disease of unknown cause resulting in fibrous induration of the corpora cavernosa of the penis. An association with Dupuytren's contracture of the palm has been recognized. The chief symptom of Peyronie's disease is painful erection. Palliative treatment includes radiation therapy and intralesional corticosteroid injections. There is no known cure.
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Peyronie's disease

Peyronie's disease

Curvature of penis, penile fibromatosis Urology A condition characterized by unilateral fibrotic nodules within the fascial sheath of one or both corpora cavernosa, leading to penile shaft curvature and painful erection. Cf Erectile dysfunction.

Peyronie's disease

A disorder of the penis in which the organ is bent at an angle when erect. This is the effect of local thickening and indistensibility of the fibrous tissue sheath. The thickening may extend into the erectile tissue and the condition is liable to interfere with sexual intercourse. The cause is unknown and the treatment difficult. Corticosteroid injections may help and surgical removal of the thickened areas may be tried. (Francois de la Peyronie, 1678–1747, French surgeon).
References in periodicals archive ?
Use of intralesional verapamil to dissolve Peyronie's disease plaque: A long-term single blind study.
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Many researchers believe the plaque of Peyronie's disease develops following trauma (hitting or bending) that causes localized bleeding inside the penis.
Compiled by the site's team of physician experts, the links take patients and clinicians to what are considered to be pivotal, peer-reviewed articles on research and data exploring the causes and treatments of Peyronie's disease.
Recent demographic surveys have reported that Peyronie's disease, also known as penile curvature, can be found in up to nine percent of men between the ages of 40 and 70.
com, an informational microsite dedicated to educating physicians, men and their partners about the symptoms, treatment options and latest research on Peyronie's disease, a common form of erectile dysfunction affecting more than 1.
Zahalsky published his groundbreaking results using amniotic stem cells and growth factors for Peyronie's Disease.
ATLANTA -- (AUA Annual Meeting) In conjunction with the American Urological Association's Annual Meeting in Atlanta, Cook Urological today announced that it will highlight a new product, Surgisis(R) ES(TM), for the treatment of Peyronie's disease.
Peyronie's Disease can run in families, but for most men it comes out of the blue.
Male sexual dysfunction includes erectile dysfunction (ED), loss of libido, premature ejaculation and Peyronie's Disease.
Asahi Kasei Pharma Corporation (Asahi Kasei) has the rights to develop and market XIAFLEX, for the treatment of Dupuytren's contracture and Peyronie's disease in Japan, through an agreement with BioSpecifics' partner Endo International plc (Endo).
My GP thinks I might have a condition called Peyronie's disease and has referred me to a specialist.