PEX14

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PEX14

A gene on chromosome 1p36.22 that encodes peroxin-14, a peroxisomal membrane protein that is an integral part of the peroxisomal import machinery, acting as a transcriptional co-repressor and interacting with a histone deacetylase. 

Molecular pathology
PEX14 mutations cause peroxisome biogenesis spectrum disorders—e.g., Zellweger syndrome.
References in periodicals archive ?
Ten peroxins including Pex1p, Pex2p, Pex5p, Pex6p, Pex7p, Pex10p, Pex12p, Pex13p, Pex14p, and Pex26p are involved in protein import into peroxisomal matrix (24), (34), (90) (Fig.
PTS1 proteins are transported by homo- and hetero-oligomers of Pex5pS and Pex5pL to peroxisomes, where Pex14p of an 800-kDa complex functions as the initial Pex5p-docking site (Fig.
1999) Identification and characterization of the human orthologue of yeast Pex14p.
2008) The peroxin Pex14p is involved in LC3-dependent degradation of mammalian peroxisomes.