econazole

econazole

 [ĕ-kon´ah-zōl]

an imidazole derivative used as the nitrate salt as a broad-spectrum antifungal agent, applied topically in the treatment of cutaneous candidiasis and various forms of tinea.

econazole

/econ·a·zole/ (ĕ-kon´ah-zōl) an imidazole derivative used as the nitrate salt as a broad-spectrum antifungal agent.

econazole

(ĭ-kŏn′ə-zōl′)

n.

A broad-spectrum antifungal agent used in the treatment of athlete's foot and related fungal infections.

econazole

[ikon′əzōl]

a topical antifungal agent.

indications It is prescribed in the treatment of tinea pedis, tinea cruris, tinea corporis, tinea versicolor, and candidiasis.

contraindication Known sensitivity to this drug prohibits its use.

adverse effects Among the most serious adverse effects are local irritation and hypersensitivity of the skin.

econazole

A broad-spectrum antifungal drug used in local (topical) application. Brand names are Ecostatin, Pevaryl, Pevaryl TC and Gyno-Pevaryl.

econazole

; Pevaryl broad-spectrum, topical, imidazole, antifungal agent used (as 1% cream) to treat candidal and tinea skin infections (see Table 1)

Table 1: Treatment of fungal infections of skin and nails

Infection site	Agent
	Antimycotic agent (for the treatment of dermatophytosis)
Skin	Topical allylamine (e.g. 1% terbinafine cream for 7 days) Topical imidazoles (e.g. 2% miconazole or 1% clotrimazole for 28 days) Topical 0.25% amorolfine Topical 1% econazole Topical griseofulvin spray (400 μg puff daily for 14 days) Topical 1% sulconazole Topical tea tree (manuka) oil Topical undecenoate (20% zinc undecenoate + 5% undecenoic acid) Topical Whitfield's ointment (6% benzoic acid + 3% salicylic acid) Other topicals include: weak iodine solution 2.5%; potassium permanganate paint 1%; salicylate acid cream or alcoholic solution 3-5%; benzoic acid (Whitfield's) ointment; sodium polymetaphosphate dusting powder Systemic terbinafine (250 mg daily for 2 weeks) Systemic itraconazole (100 mg daily for 15 days) Systemic griseofulvin (500 mg daily )
Nail	Topical amorolfine 0.25% lacquer as an adjunct to systemic treatment Topical borotannic acid complex acid; Phytex paint (1.46% salicylic acid + 4.89% tannic acid + 3.12% boric acid) Topical 28% tioconazole lacquer Topical undecenoate lacquer; Monphytol paint (5% methyl undecenoate + 0.7% propyl undecenoate + 3% salicylic acid + 25% methyl salicylate + 5% propyl salicylate + 3% chlorambucil) Other topicals: strong iodine 10% solution Systemic terbinafine (250 mg daily for 12-16 weeks) Systemic itraconazole (400 mg for 1 week in a month, repeated overall 3 or 4 times) Anticandidal agent (for the treatment of candidiasis)
Skin	Topical antimycotic creams (1% clotrimazole; 1% econazole; 2% miconazole) Topical nystatin (100 000 units ± 1% tolnaftate) Antipityriasis versicolor agent (for the treatment of pityriasis versicolor)
Skin	Topical 2% ketoconazole Topical 2.5% selenium sulphide Topical antimycotic agents (1% clotrimazole; 1% econazole; 2% miconazole; 1% sulconazole; 1% terbinafine) Systemic fluconazole/itraconazole/ketoconazole/miconazole/voriconazole

antifungal agent 

Any substance which destroys or prevents the growth of fungi. It is one of the antibiotic groups. There are several classes of antifungal drugs: Polyenes, which cause an increase in fungal cell wall permeability leading to its death. Examples: amphotericin B, natamycin, nystatin. Azoles, which act either by inhibiting the synthesis of ergosterol, a component of fungal cell wall or by causing direct wall damage. Examples: clotrimazole, econazole, fluconazole, itraconazole, ketoconazole, miconazole. Pyrimidines, which interfere with the normal function of fungal cells. Example: flucytosine. Syn antimycotic agent.

econazole

an imidazole antifungal agent related to miconazole; used topically as the nitrate in the treatment of fungal infections of the skin.