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trademark for preparations of dipyridamole, a coronary vasodilator used to prevent clotting associated with mechanical heart valves and as an adjunct in radionuclide myocardial perfusion imaging.


Apo-Dipyridamole FC (CA), Apo-Dipyridamole SC (CA), Persantin (UK), Persantine

Pharmacologic class: Platelet adhesion inhibitor

Therapeutic class: Antiplatelet agent, diagnostic agent (coronary vasodilator)

Pregnancy risk category B


Unclear. May reduce platelet aggregation by inhibiting phosphodiesterase, adenosine uptake, or formation of thromboxane A2.


Tablets: 25 mg, 50 mg, 75 mg

Indications and dosages

To prevent thromboembolism in patients with prosthetic heart valves

Adults: 75 to 100 mg P.O. q.i.d.

Off-label uses

• Prevention of myocardial reinfarction (given with aspirin)

• Thrombotic thrombocytopenia purpura


• Hypersensitivity to drug


Use cautiously in:

• hypotension, hepatic insufficiency, severe coronary artery disease

• pregnant or breastfeeding patients

• children younger than age 12 (safety not established).


• Know that drug is usually given with warfarin when used to prevent thromboembolism.

• Give with a full glass of water at least 1 hour before or 2 hours after meals. If gastric distress occurs, give with food.

Adverse reactions

CNS: dizziness, headache

CV: hypotension

GI: abdominal distress

Hepatic: hepatic failure

Skin: rash


Drug-drug. Adenosine: increased adenosine plasma level and CV effects

Cholinesterase inhibitors: counteracts activity of cholinesterase inhibitors

Drug-diagnostic tests. Hepatic enzymes: increased levels

Drug-behaviors. Alcohol use: increased risk of hypotension

Patient monitoring

• Monitor for therapeutic efficacy, including improved exercise tolerance and decreased need for nitrates.

• Assess platelet and coagulation studies regularly.

• Monitor ECG and vital signs, especially blood pressure.

• Monitor hepatic function tests regularly.

Patient teaching

• Advise patient to take drug 1 hour before or 2 hours after meals for best absorption.

Instruct patient to immediately report unusual tiredness, chest pain or other cardiac symptoms, upper right abdominal pain, yellowing of skin or eyes, or dark urine.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.


a trademark for an inhibitor of platelet aggregation (dipyridamole).


Cardiology A formulation of dipyridamole used as an alternative to exercise in thallium myocardial perfusion imaging for evaluating CAD in Pts who cannot exercise adequately. See Exercise stress test.
References in periodicals archive ?
Patients pharmacologically stressed by either adenosine or persantine (dipyridamole) were NPO for 4 hours prior to administration and discontinued persantine products for 24 hours.
In cases where the cardiologist indicated a preference and for patients with low heart rates (less than 60 beats per minute), persantine (dipyridamole) was used as a pharmacological inducer.
The FDA-approved indications for Persantine in the 1987 PDR reads thus: "Possibly effective for long-term therapy of chronic angina pectoris.
Once the indications for Persantine changed, sales plummeted; 7 years later, no form of dipyridamole remains on the top-200 list.
One could easily forget that prescribing Persantine in 1987 was perfectly appropriate, based on standards of the day.
By comparison, Valium, Darvon, and Elavil each walloped Persantine on the top-200 list, 200 but none of these three is prescribed even half as often, at least by the Harvard researchers' estimates.
HYDERABAD, India -- All currently available antiplatelet drugs viz- Aspirin, PLAVIX(R), Persantine, Aggrastat, and Ticlid are toxic.
Syncor will in turn provide to Mallinckrodt access to DuPont Merck's Cardiolite, Neurolite and Persantine, of which Syncor has exclusive and/or preferred distribution rights.