Glans cancer frequently arises from the periurethral glands
of Littre, bulbar Cowper, and sweat glands.
The etiology of acquired urethral diverticula is recurrent infection of the periurethral glands
with obstruction, suburethral abscess formation, and rupture of the glands into the urethral lumen.
3,5) Evidence of prostatic differentiation has been reported within the periurethral glands
of Littre along the entire length of the urethra, (4) as well in cystitis cystica/glandularis in 1 study, (15) suggesting that a metaplastic origin of EPT from these entities may be plausible.
An acquired urethral diverticulum is the sequelae of infection in the periurethral glands
that progresses to fistulization into the urethra.
Although some may be congenital, most cases are thought to be acquired secondary to rupture of infected periurethral glands into the urethral lumen.
6) The distinct predominance of adenocarcinoma may support the "acquired" nature of most female diverticula and their origin from the periurethral glands.
But it now appears that the most likely cause of urethral diverticula is infection and obstruction of the periurethral glands
with subsequent cyst formation and rupture, Dr.
The periurethral glands
do not significantly influence the serum prostate specific antigen concentration.
Immunoreactive prostatic specific antigen in male periurethral glands.
An analysis of urinary prostatic specific antigen before and after radical prostatectomy: evidence for secretion of prostatic specific antigen by the periurethral glands.
Although a placental origin of PSA during pregnancy has not yet been investigated, possible sources of maternal serum PSA may include diffusion from amniotic fluid, production by the periurethral glands
[15-17], and secretion from breast tissue in response to steroid stimulation during pregnancy .
Immunohistochemical identification of PSA in female periurethral glands