peritubular capillaries


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peritubular capillaries

Blood capillary beds surrounding the renal tubules of nephrons.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
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However, neither flow cytometry crossmatch nor donor-specific antibodies (DSAs) for HLA class I or II, including HLA-A, B, C, DR, DQ, and DP, were found in serum samples, and the peritubular capillaries did not show C4d staining by immunohistochemistry.
(22,23) In this study, pre-transplant PRA level was found to have no value in predicting either the antibody-mediated rejection or C4d deposition on peritubular capillaries. Statistically significant correlation (p < 0.
Kidney C4d Staining and Interpretation.--C4d staining should be assessed in peritubular capillaries of nonatrophic renal parenchyma (Figure 1, A and B), either cortex or medulla; an adequate sample is currently defined as 5 high-power fields.
The renal artery small branching order afferent arterioles lead to the glomerular capillaries and the distal ends of the capillaries of each glomerulus join together to form the efferent arterioles, followed by a second capillary network constituted by the peritubular capillaries surrounding renal tubules.
Fluorescent study did not show any immunoglobulin or complement, while there was a diffuse attachment of C4d along the peritubular capillaries (Figure 4).
The cardinal features observed in biopsy series included (i) light microscopy identifying a duplication of glomerular basement membrane (GBM), mesangial matrix expansion, and glomerulitis, (ii) electron microscopy (EM) identifying a loss of endothelial fenestration, endothelial cell swelling, and mesangial matrix expansion, and (iii) immunofluorescence identifying mesangial IgM and C3 staining [+ or -] C4d in glomerular cells and peritubular capillaries [15,16].
Other recent studies have also showed mononuclear cells in glomerular and peritubular capillaries though the number of leukocytes was not significantly different between the ARF group and the non-ARF group (62,63).
Results: All 16 patients (100%) showed deposition of C4d in the glomerular structures, and one also had focal deposition of C4d in the peritubular capillaries.
Several pathways exist for the movement of ions and water between the tubule and the peritubular capillaries. One route is the transcellular pathway in which a solute traverses through the epithelial cells lining the tubules, moving through both the luminal and basolateral membranes.
C4d stain was negative in the peritubular capillaries and glomerular capillaries.
In a recent study, we found that transplant glomerulopathy, a principal form of late ABMR, had a significant increase in T-bet expression in peritubular capillaries (PTC), and this expression was strongly correlated with the count of intra-PTC inflammation cells.
The US Food and Drug Administration approved agalsidase beta in 2001 following a clinical study in which a reduced amount of GL-3 inclusions in endothelial cells of renal peritubular capillaries (PTCs) was demonstrated after a period of intermittent intravenous treatment with this recombinant enzyme.