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The space between the cell membranes and the cell wall, in gram-negative bacteria; contains proteins secreted by the cell.


The region between the cytoplasmic membrane and the outer cell membrane in gram-negative bacteria and some archaea.

per′i·plas′mic adj.
References in periodicals archive ?
coli cells grown on NaCl-betaine containing medium appeared normal, displaying intact and distinct outer membrane and cytoplasmic membrane enclosing a periplasmic space.
coli cells including the outer and cytoplasmic membrane and enclosed periplasmic space, the nucleoid and ribosomes in the cytoplasm are severely altered and/or destroyed in a NaCl containing medium, but are restored to their normal form in a NaCl-betaine containing medium.
Similarly, Shiga toxin was also found to be released as OMVs from periplasmic space of Shigella dysenteriae and that the secretion was induced by an antimicrobial compound, mitomycin C (43).