periodic acid-Schiff stain

(redirected from Periodic acid-schiff reaction)

per·i·od·ic ac·id-·Schiff stain (PAS),

a tissue-staining procedure in which 1,2-glycol groupings are first oxidized with periodic acid to aldehydes that then react with the sulfite leucofuchsin reagent of Schiff and turn red-violet; strong staining occurs with polysaccharides, such as glycogen, and mucopolysaccharides of epithelial mucins, basement membranes, and connective tissue.
Synonym(s): PAS stain


Hugo, German chemist in Florence, 1834-1915.
Kasten fluorescent Schiff reagents - see under Kasten
ninhydrin-Schiff stain for proteins
periodic acid-Schiff stain - a tissue-staining procedure. Synonym(s): PAS stain
Schiff base - condensation products of aldehydes and ketones with primary amine. Synonym(s): aldimine
Schiff reagent - used for aldehydes and in histochemistry to detect polysaccharides, DNA, and proteins.

per·i·od·ic ac·id-Schiff stain

(PAS) (pērē-odik asid shif stān)
A clinical tissue-staining procedure.
References in periodicals archive ?
Moreover, we performed phosphotungstic acid-hematoxylin, Ziehl-Neelsen stain, periodic acid-Schiff reaction, periodic acid-Schiff diastase reaction, and Grocott histochemical stains.
2) They were also positive for periodic acid-Schiff reaction but not for acid-fast staining.
Light and electron microscopic correlation of the periodic acid-Schiff reaction in the human plasma cell.
There was a positive periodic acid-Schiff reaction following diastase digestion within apical cytoplasmic tips (Figure, B).

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