We also investigated the relationship between clinicopathological features of PCa, such as Gleason scores, presence of extraprostatic invasion, perineural invasion, positive margin resection, seminal vesicle invasion, and NLR, PLR and NMR.
(6,7,14) In our study, patients with close margins who received postoperative RT had significantly more nodal involvement, significantly more advanced cancer stage, and a significantly greater frequency of perineural invasion than did patients with close surgical margins who did not receive RT.
All lesions were pT1 (n=51) or pT2 (n=23), with 1 lesion displaying lymphovascular invasion and 4 lesions with (5.5%) perineural invasion. Mean excision margins were 4.5mm peripherally (range <1-13mm, SD 2.6mm) and 4.0 mm deep (range <1mm-16mm, SD 3.5mm).
Histology identified changes consistent with Adenoid Cystic Carcinoma of the BG involving surgical margins with perineural invasion. The tumour showed extensive cribriform and tubular islands of malignant epithelium infiltrating hyaline stroma, containing intraluminal basement membrane like material.