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Therapeutic: hormones
Pharmacologic: gonadotropins
Pregnancy Category: X


Used in conjunction with chorionic gonadotropin to stimulate ovulation in patients with ovarian dysfunction and resultant infertility.Used in conjunction with chorionic gonadotropin to stimulate spermatogenesis in male patients with hypogonadotropic hypogonadism and resultant infertility.As part of assisted reproductive technologies (ART) to stimulate the production of multiple oocytes in ovulatory patients.


A purified form of human pituitary gonadotropins consisting of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). In women, FSH causes growth and maturation of the ovarian follicle. LH causes ovulation and development of the corpus luteum. In men, LH causes spermatogenesis.

Therapeutic effects

Ovulation or spermatogenesis, with resultant fertility.


Absorption: Appears to be well absorbed after IM administration.
Distribution: Unknown.
Metabolism and Excretion: 8% excreted unchanged in the urine.
Half-life: FSH—70 hr; LH—4 hr.

Time/action profile (effects on reproductive function†)

IM, subcut (women)unknown18 hrunknown
IM (men)unknown4 mounknown
†Women—peak = ovulation after chorionic gonadotropins; men—peak = increased spermatogenesis


Contraindicated in: Vaginal bleeding of unknown cause; Uterine fibroid tumors; Ovarian cysts; Pregnancy.
Use Cautiously in: Asthma; CV disease; Seizure disorders; Migraine headaches; Polycystic ovaries; Pituitary hypertrophy or tumor; Severe renal impairment.

Adverse Reactions/Side Effects


  • thromboembolism (life-threatening)
  • edema
  • thrombophlebitis


  • abdominal pain (most frequent)
  • bloating (most frequent)
  • diarrhea
  • nausea
  • vomiting


  • pelvic pain (most frequent)
  • multiple births
  • ovarian enlargement


  • gynecomastia (men)


  • fever


Drug-Drug interaction

None significant.


Subcutaneous Intramuscular (Adults) Repronex—Infertile patients with oligo-anovulation—150 units FSH and 150 units LH daily for first 5 days of treatment after GnRH agonist or antagonist pituitary suppression, dosage adjustments may be made every 2 days and should not exceed 75–150 units/adjustment (not to exceed 450 units/day or more than 12 days of therapy). If response is appropriate, hCG should be given after discontinuation of menotropins. Assisted reproduction technologies—225 units FSH and 225 units LH daily after GnRH agonist or antagonist pituitary suppression, dosage adjustments may be made every 2 days and should not exceed 75–150 units/adjustment (not to exceed 450 units/day or more than 12 days of therapy) followed by chorionic gonadotropin.
Intramuscular (Adults —females) Pergonal—75 units FSH and 75 units LH/day for 7–12 days followed by hCG if ovaries are not enlarged. If pregnancy does not occur, dose may be doubled for 2–3 more courses.
Intramuscular (Adults —males) Pergonal—following pretreatment with hCG alone, 75 units FSH activity and 75 units LH 3 times weekly concurrently with hCG, dose may be doubled if ineffective after 4 mo.


Powder for injection: 75 units FSH activity and 75 units LH activity in vial, 150 units FSH activity and 150 units LH activity in vial

Nursing implications

Nursing assessment

  • Female Infertility: Gynecologic and endocrine examinations to determine the cause of infertility should be completed before therapy. The patient’s partner should also be evaluated for possible decreased fertility. An endometrial biopsy should be performed in older patients to rule out the presence of endometrial carcinoma.
  • Ultrasound exams are recommended during menotropin therapy and before administration of chorionic gonadotropin.
  • Male Infertility: Urologic and endocrine examinations to determine the cause of infertility should be completed before therapy.
  • Lab Test Considerations: In female infertility, cervical mucus volume and character, serum estradiol levels, serum or urine progesterone concentrations, and ultrasound may be used to determine whether follicular maturation has occurred.
    • In male infertility, serum testosterone, sperm count, and motility should be evaluated before and after course of therapy.

Potential Nursing Diagnoses

Sexual dysfunction (Indications)
Disturbed body image (Indications)


  • Female infertility—chorionic gonadotropin is usually administered 1 day after course of human menotropins. Male infertility—chorionic gonadotropin is administered alone until secondary sex characteristics develop, then administered concurrently with menotropins.
  • Subcutaneous: Alternating sites in the lower abdomen should be used for subcut injection.
  • Intramuscular: Reconstitute powder with 2-mL vial of 0.9% NaCl for injection provided by manufacturer. Use immediately; discard any unused portion of dose.

Patient/Family Teaching

  • Instruct patient in correct technique for medication reconstitution and administration of IM injection. Ensure that patient understands medication administration schedule.
  • Female Infertility: Instruct patient in the correct method for measuring basal body temperature. A record of the daily basal body temperature should be maintained before and throughout course of therapy.
    • Reinforce physician’s instructions regarding timing of sexual intercourse (usually daily beginning 1 day after administration of chorionic gonadotropin).
    • Emphasize the importance of close monitoring by the physician throughout course of therapy (daily pelvic examinations are indicated after estrogen levels rise and for 2 wk after chorionic gonadotropin therapy).
    • Inform patient before therapy of the potential for multiple births.
    • Instruct patient to notify physician immediately if pregnancy is suspected (menses do not occur when expected and basal body temperature is biphasic).
    • Advise patient to report to physician signs and symptoms of fluid retention (swelling of ankles and feet, weight gain), thromboembolic disorders (pain, swelling, tenderness in extremities, headache, chest pain, blurred vision), or abdominal or pelvic pain or bloating.
  • Male Infertility: Inform patient that breast enlargement may occur. Physician should be consulted if this is problematic.

Evaluation/Desired Outcomes

  • Follicular maturation in women. Menotropin therapy is followed by human chorionic gonadotropin, which should lead to ovulation with subsequent pregnancy. If ovulation does not occur after any cycle, therapeutic regimen should be re-evaluated. If ovulation does not occur after 3 cycles, appropriateness of continuation of menotropin therapy should be reconsidered.
  • Increased spermatogenesis after 4 mo of therapy in men.
Drug Guide, © 2015 Farlex and Partners


A brand name for MENOTROPHIN.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Gonadotropins used in the study for follicle stimulation were pregnant mare serum gonadotropin (PMSG; Sigma, India), folligon (contains both FSH & LH; Intervet, Netherlands), pergonal (human menopausal gonadotropin; Serono, USA) and for induction of ovulation was human chorionic gonadotropin (hCG; Sigma, India).
For both studies controlled ovarian stimulation was achieved using a long protocol of gonadotrophin-releasing hormone (GnRH) agonist (Synarel; Montosano South Africa, Searle) followed by human menopausal gonadotrophin (hMG) (Pergonal; Serono, South Africa (Pty) Ltd) and/or pure FSH (Metrodin; Serono) from cycle day 3.
Don't you ever worry, I hinted, about ovarian cancer after Pergonal? The statistics?
On This Day: 1997: The world's only known set of living septuplets were born: 'To us they aren't the septuplets, they are our children,' said Iowa mother, former seamstress Bobbi McCaughey, who had taken a fertility drug known as Pergonal. The children, delivered by caesarean section, were all in a stable condition.
Mrs McCaughey, a seamstress, conceived with the help of Pergonal - the powerful fertility drug used by Mandy Allwood, whose eight babies all died.
Bobbi, 29, got pregnant after taking fertility drug pergonal.
McCaughey, who left her seamstress job before giving birth to her first child nearly two years ago, had been taking the fertility drug Pergonal. The drug had been prescribed because she and her husband, Kenny, had trouble conceiving daughter Mikayla, who's almost 2 now.
A few weeks later I was home in time to begin turning her backside into a pincushion, shooting doses of Pergonal and Metrodin, to begin stimulating egg development, into her buttocks morning and night.
Perhaps a more important thing to consider with these technologies is the medical risks and complications associated with ovary-stimulating drugs in general--especially Pergonal injections.
So determined, in fact, that Monica even endured injections of pergonal and other fertility drugs prior to the in-vitro procedure.
Patients typically receive Lupron (leuprolide acetate), which suppresses their hormonal system, and Pergonal (menotropins for injection), which stimulates egg production.
Finally, the use of fertility drugs, chiefly Clomid and Pergonal, genetically increases the likelihood of multiples.