Kodadek, Quantitative evaluation of the relative cell permeability of peptoids
Part II then discusses synthesis and particular mimetic molecules in more detail, including bioisosteres, solid-phase synthesis, combinatorial approaches, click chemistry with triazole scaffolding, peptoids
, sugar amino acids as scaffolds, cyclic alpha-amino acids as proline mimics, beta-turn mimetics, and foldamers, including material on both structure-function relationships and synthesis.
Besides scanning proteins for B- and T-epitope motifs [6-12], kinase phosphorylation and other posttranslational modification sites [13-17], and studies of protease cleavage specificity [16,18], multiple parallel peptide synthesis is employed for the search of antibacterial peptides , receptor peptide ligands , and preparation of novel biomaterials based on readily structured peptides and peptoids
The two parties will collaborate on developing OPKOa[euro](tm)s pipeline of proprietary peptoids
and other molecules for diagnostic and therapeutic products, the chairman and CEO of the buyer, Phillip Frost, said in a press release.
The companies will now join forces to develop a pipeline of proprietary peptoids
and other molecules for diagnostic and therapeutic products, said Phillip Frost, chairman and chief executive officer of OPKO.
The new study, however, challenges conventional wisdom and uses synthetic molecules (peptoids
) rather than antigens to successfully detect signs of disease in a patient's blood samples.
The new study uses synthetic molecules (peptoids
), which can be modified easily and can be produced quickly in relatively large amounts at lower cost.
Their research was published in a recent issue of the Journal of the American Chemical Society.The scientists worked with chains of bioinspired polymers called a peptoids
are structures that mimic peptides, which nature uses to form proteins, the workhorses of biology.
The scientists deployed a large library of randomly selected, unnatural molecules known as ' peptoids
' to screen for antibodies found in the bloodstream.
It involves using synthetic molecules called peptoids
to "fish" for disease-specific antibodies in the blood.
The earliest examples are simple oligo(N-alkylated)glycines (or peptoids
), which bear tertiary amide units that confer protease resistance and side-chain diversity [ILLUSTRATION FOR FIGURE 1 OMITTED].
It will enable OPKO to further develop its "pipeline of proprietary peptoids
and other molecules for diagnostic and therapeutic products, while providing revenues and profits," he added.