Peptidyltransferase | definition of peptidyltransferase by Medical dictionary
The enzyme responsible for the formation of the peptide bond on the ribosome during protein biosynthesis, peptidyl-tRNA1 + aminoacyl-tRNA2 → tRNA1 + peptidylaminoacyl-tRNA2.
References in periodicals archive
However, rapidly growing mycobacteria can develop resistance by mutations in the peptidyltransferase
region of the 23S ribosome gene (24).
DON binds to RNA peptidyltransferase
site and inhibits protein synthesis (De Walle et al.
Structure and function of rRNA in the decoding domain and at the peptidyltransferase
The cycloheximide inhibits peptidyltransferase
, which is responsible for peptide bond synthesis during translation (26).
Erythromycin binds to the ribosome but, unlike larger macrolides, appears to cause dissociation of the peptidyl-tRNA, rather than blocking the peptidyltransferase