peptidoglycan

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Related to Peptidoglycans: murein, Proteoglycans

peptidoglycan

 [pep″tĭ-do-gli´kan]
a glycan (polysaccharide) attached to short cross-linked peptides; found in bacterial cell walls.

pep·ti·do·gly·can

(pep'ti-dō-glī'kan),
A compound containing amino acids (or peptides) linked to sugars, with the latter preponderant. Compare: glycopeptide.
Synonym(s): mucopeptide (2)

peptidoglycan

(pĕp′tĭ-dō-glī′kən, -kăn′)
n.
A polymer found in the cell walls of prokaryotes that consists of polysaccharide and peptide chains in a strong molecular network. Also called mucopeptide, murein.

pep·ti·do·gly·can

(pep'ti-dō-glī'kan)
A compound containing amino acids (or peptides) linked to sugars, with the latter preponderant.
Compare: glycopeptide

peptidoglycan

a main component of bacterial CELL WALLS. Peptidoglycan consists of molecules of SUGARS: N-acetylglucosamine and N-acetylmuramic acid, linked together in rows (forming the glycan portion of peptidoglycan), and adjacent rows are cross-linked by PEPTIDES (forming the peptide portion of peptidoglycan). Peptidoglycan forms a lattice that surrounds and protects the whole cell. Generally, Gram-positive BACTERIA (see GRAM'S STAIN have many layers of peptidoglycan, forming a thick and rigid layer, while gram-negative bacteria have a thin layer of peptidoglycan.
References in periodicals archive ?
PGRPs influence host-pathogen interactions not only through their antibacterial or peptidoglycan hydrolytic properties (Yang et al., 2017), but also through their pro-inflammatory and anti-inflammatory properties that are independent of their hydrolytic and antibacterial activities (Wang et al., 2016a).
Penicillin works by blocking this linking of peptidoglycans, thus causing the bacteria cell walls to remain fragile.
Small intestine bacterial overgrowth--increased levels of commensal flora in a highly absorptive mucosal region--is associated with over 40 major illnesses and provides a major burden of LPS, peptidoglycans, and cytokines.
Bacterial cell wall components, such as endotoxin (present only in Gram-negative bacteria) and peptidoglycans (most prevalent in Gram-positive bacteria), are agents with important pro-inflammatory properties that may induce respiratory symptoms.
This inhibits the synthesis of peptidoglycan in the bacterial cell walls by interacting with D-Ala-D-Al-pentapeptide at C-terminus and preventing their addition to the peptidoglycan chain [21].
Based on the origin of plastids from an endosymbiotic cyanobacterium, PpPBP must localize to the intermembrane space where peptidoglycan is present, because PBPs function in the periplasm where new peptidoglycan monomer units join pre-existing peptidoglycans in bacteria.
Examination of peptidoglycans in the work environment is not yet as prevalent as in the case of endotoxins [15-17].
Keywords: Lysinibacillus pakistanensis; Cell wall peptidoglycans type A4a; DNA-DNA hybridizationIntroduction
While the SSAg predominantly activate T cells of the adaptive immune system through TCR, certain other staphylococcal components such as the cell wall peptidoglycans, lipoteichoic acid, lipoproteins, unmethylated bacterial DNA containing the CpG motifs and even the intact bacteria, collectively called pathogen-associated molecular patterns (PAMPs), can activate the immune system through pathogen recognition receptors (PRR) comprising the toll-like receptors (TLR) and the NOD-like receptors (NLR), expressed by cells of both innate and adaptive arms of the immune system [9-11].
Purification and quantitative chemical analysis of cell wall peptidoglycans of Leptotrichia buccalis.
Reg3[gamma] is essential to keep a 50 [micro]m bacteria-free zone above the small intestine epithelial surface and the antimicrobial effect is related to the capacity of specifically targeting native peptidoglycans on bacterial surfaces [103].
Inactivation of bacteria by ozone is a complex process once ozone attacks numerous cellular constituents, including proteins, unsaturated lipids and respiratory enzymes in cell membranes, peptidoglycans in cell wall, enzymes and nucleic acids in the cytoplasm, and proteins and peptidoglycan in spore coats and virus capsids.