We are currently looking into designing small molecules such as specific peptide nucleic acids
, which are stable and can be easily delivered to block the cancer-driven RNA editing process, said Prof Tan, who is also from the Duke-NUS Medical School and Genome Institute of Singapore (GIS).
This has been an ongoing challenge of molecular biologists, with few approaches emerging, such as peptide nucleic acids
(PNA), triplex forming oligonucleotides (TFO), minor groove binding polyamides, and engineered proteins.
The answer may be AEG, a small molecule that when linked into chains forms a hypothetical backbone for peptide nucleic acids
, which have been hypothesized as the first genetic molecules.
Some analogs such as Peptide Nucleic Acids
(PNA) are fairly stable.
Peptide nucleic acids
(PNAs) as diagnostic devices for genetic and cytogenetic analysis.
He will present his group's work on the synthesis and properties of nucleobase-modified peptide nucleic acids
at the 7th International Symposium on BiomolecularChemistry (ISBOC-7) held at the University of Sheffield, U.
The functional domain could be created with a variety of backbone modifications, including second-generation chemistry, peptide nucleic acids
, and locked nucleic acids.
18 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDE NUCLEIC ACIDS
AND THEIR ANALOGUES
The new entities will be developed by exploiting the design principles of small aromatic building blocks to arrive at the smallest possible module that form super helical assembly based on the coiled coil motifs and establishing peptide nucleic acids
based systems to combine the worlds of peptide and DNA nanotechnologies.
Stability of peptide nucleic acids
in human serum and cellular extracts.
those containing peptide nucleic acids
(PNAs) as detection elements.
Advanced Viral Research is a biotechnology company specializing in the development of peptide nucleic acids
for pharmaceutical use.