pepsinogen

(redirected from Pepsinogens)
Also found in: Dictionary, Thesaurus, Encyclopedia.

pepsinogen

 [pep-sin´o-jen]
a zymogen secreted by the chief cells of the gastric glands and converted into pepsin in the presence of gastric acid or of pepsin itself.

pep·sin·o·gen

(pep-sin'ō-jen), [MIM*169700]
A proenzyme or zymogen formed and secreted by the chief cells of the gastric mucosa; the acidity of the gastric juice and pepsin itself remove 44 amino acyl residues from pepsinogen to form active pepsin.
Synonym(s): propepsin
[pepsin + G. -gen, producing]

pepsinogen

/pep·sin·o·gen/ (pep-sin´ah-jin) a zymogen secreted by the chief cells of the gastric glands and converted into pepsin in the presence of gastric acid or of pepsin itself.

pepsinogen

(pĕp-sĭn′ə-jən)
n.
The inactive precursor to pepsin, formed in cells of the mucous membrane of the stomach and converted to pepsin by autocatalysis in the presence of hydrochloric acid.

pepsinogen

[pəpsin′əjən]
Etymology: Gk, pepsis + genein, to produce
a zymogenic substance secreted by pyloric and gastric chief cells. It is converted to the enzyme pepsin in an acidic environment, as in the presence of hydrochloric acid produced in the stomach.

pep·sin·o·gen

(pep-sin'ŏ-jen)
A proenzyme formed and secreted by the chief cells of the gastric mucosa; the acidity of the gastric juice and pepsin itself remove 42 amino acid residues from pepsinogen to form active pepsin.
Synonym(s): propepsin.
[pepsin + G. -gen, producing]

pepsinogen

A biochemically inert substance produced by the cells of the stomach lining (gastric mucosa) that is converted to PEPSIN by the action of hydrochloric acid.

pepsinogen

a precursor of PEPSIN in the vertebrate stomach which, in the presence of hydrochloric acid (also secreted by the OXYNTIC CELLS in the stomach wall), gives rise to more active pepsin, which itself activates pepsinogen. The reaction is thus auto catalytic.

pepsinogen

a zymogen secreted by the chief cells of the gastric glands and converted into pepsin in the presence of gastric acid or of pepsin itself.

plasma pepsinogen
high levels are indicative of extensive mucosal damage in the abomasum, as in ostertagiasis in ruminants.
References in periodicals archive ?
Miki K, Miki K, Ichinose M, Yahagi N (1977) Efficiency of gastric screening system using serum pepsinogen test.
1987) Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels.
1998) Correlation of ratio of serum pepsinogen I and II with prevalence of gastric cancer and adenoma in Japanese subjects.
With purified human pepsinogens A and C (clinically called pepsinogens I and II, respectively) at hand, we explored for the clinical use of them in collaboration with K.
We extended our structure-function studies on pepsinogens and pepsins to those on other homologous aspartic peptidases, including human pepsinogens and pepsins 126),127) and non-mammalian pepsinogens and pepsins, (128-133) cathepsin D, (92,134-138) cathepsin E, (139-149) filarial parasite aspartic peptidases (from Brugia malayi), (150) HIV-1 protease, (151,152) Drosophyla copia protease, (153) rhizopuspepsin (from Rhizopus chinensis), (154,155) and aspergillopepsin I (from Aspergillus niger).
1983) Purification and characterization of pepsinogens and pepsins from asiatic black bear, and amino acid sequence determination of the [NH.
Using low pepsinogen 1:2 ratio as a marker of atrophy, 6/14 (43%) of patients with intestinal metaplasia did not have atrophy, and none of the patients with intestinal metaplasia had atrophy as assessed by low serum gastrin-17.
Median (IQR) pepsinogen 1:2 ratio was lower in current smokers (cases and controls combined, as few controls were smokers) than in non-smokers (1.
1989) The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis.
1993) Clinical application of serum pepsinogen I and II levels for mass screening to detect gastric cancer.
Four mouse mAbs and one rabbit polyclonal Ab were prepared and used to develop a pepsinogen C immunofluorometric assay.
The detection limit, defined as the concentration of pepsinogen C corresponding to the fluorescence of the zero calibrators plus two SDs, is 0.