pepsinogen

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pepsinogen

 [pep-sin´o-jen]
a zymogen secreted by the chief cells of the gastric glands and converted into pepsin in the presence of gastric acid or of pepsin itself.

pep·sin·o·gen

(pep-sin'ō-jen), [MIM*169700]
A proenzyme or zymogen formed and secreted by the chief cells of the gastric mucosa; the acidity of the gastric juice and pepsin itself remove 44 amino acyl residues from pepsinogen to form active pepsin.
Synonym(s): propepsin
[pepsin + G. -gen, producing]

pepsinogen

/pep·sin·o·gen/ (pep-sin´ah-jin) a zymogen secreted by the chief cells of the gastric glands and converted into pepsin in the presence of gastric acid or of pepsin itself.

pepsinogen

(pĕp-sĭn′ə-jən)
n.
The inactive precursor to pepsin, formed in cells of the mucous membrane of the stomach and converted to pepsin by autocatalysis in the presence of hydrochloric acid.

pepsinogen

[pəpsin′əjən]
Etymology: Gk, pepsis + genein, to produce
a zymogenic substance secreted by pyloric and gastric chief cells. It is converted to the enzyme pepsin in an acidic environment, as in the presence of hydrochloric acid produced in the stomach.

pep·sin·o·gen

(pep-sin'ŏ-jen)
A proenzyme formed and secreted by the chief cells of the gastric mucosa; the acidity of the gastric juice and pepsin itself remove 42 amino acid residues from pepsinogen to form active pepsin.
Synonym(s): propepsin.
[pepsin + G. -gen, producing]

pepsinogen

A biochemically inert substance produced by the cells of the stomach lining (gastric mucosa) that is converted to PEPSIN by the action of hydrochloric acid.

pepsinogen

a precursor of PEPSIN in the vertebrate stomach which, in the presence of hydrochloric acid (also secreted by the OXYNTIC CELLS in the stomach wall), gives rise to more active pepsin, which itself activates pepsinogen. The reaction is thus auto catalytic.

pepsinogen

a zymogen secreted by the chief cells of the gastric glands and converted into pepsin in the presence of gastric acid or of pepsin itself.

plasma pepsinogen
high levels are indicative of extensive mucosal damage in the abomasum, as in ostertagiasis in ruminants.
References in periodicals archive ?
The gene for pepsinogen C has been cloned and sequenced [30].
Pepsinogen C is reportedly present at high concentrations in breast secretions and in breast tumor extracts.
Among these molecules are pepsinogen C, PSA, apolipoprotein D, and Zn-[[alpha].
Until now, pepsinogen C was usually studied at the mRNA level with molecular techniques such as PCR or immunohistochemistry with polyclonal Abs.
The recovery of added pepsinogen C was <100% for all biological samples tested.
On the basis of analysis of a large number of biological fluids, the highest concentrations of pepsinogen C were found in seminal plasma.
We found relatively high concentrations of pepsinogen C (up to 13 000 [micro]g/L) in breast cyst fluid.
We here report for the first time that pepsinogen C is present at easily measurable concentrations in all amniotic fluids tested.