15) The clinical presentation of epithelioid sarcoma includes penile nodularity or mass, urethral stenosis, penile curvature
, dysuria and pain during erection.
3) Controlled studies with intralesional collagenase demonstrated significant benefits in penile curvature
in patients with less severe forms of PD.
A post-hoc analysis of data from the IMPRESS studies suggests that improvements in Peyronie's disease bother correlates with improvements in Peyronie's disease penile curvature
deformity, further reinforcing the previously demonstrated conclusion that Peyronie's disease bother is a valid clinical assessment.
I believe these findings are significant and further reinforce that in addition to penile curvature
deformity, PD bother should be considered when evaluating patients for treatment," said Larry I.
Surgisis[R] Biodesign[TM] for Peyronie's Repair- Last year, Cook emerged as a leader in the treatment of penile curvature
caused by Peyronie's disease.
We are excited about bringing SIS Technology to the treatment of penile curvature
and furthering Cook Urological's commitment to improving the quality of life for patients.
75 percent of men with PD treated with XIAFLEX in the IMPRESS pivotal studies had a clinically meaningful improvement in their penile curvature
deformity by the end of the trials.
EU, Canada and Australia for the treatment of adult Dupuytren's contracture (DC) patients with a palpable cord and for the treatment of adult men with PD with a palpable plaque and penile curvature
deformity of at least 30 degrees at the start of therapy in the U.
PD can result in varying degrees of penile curvature
deformity and disease bother, encompassing concern about erection pain, erection appearance and the impact of PD on intercourse and on frequency of intercourse.
Clinical Efficacy of Collagenase Clostridium Histolyticum in the Treatment of Peyronie's Disease by Baseline Penile Curvature
Severity Stratum: Results from Two Large Double-Blind, Randomized, Placebo-Controlled Phase 3 Studies (Session XVI A - Concurrent Moderated Posters - Poster Session VI - Peyronie's & Cosmesis, Saturday, November 23 at 2:45 p.
In IMPRESS I and IMPRESS II at 52 weeks, both co-primary endpoints met statistical significance for mean percent improvement in penile curvature
deformity and mean improvement in the PDQ bother domain for XIAFLEX subjects vs.
Auxilium) and assessed XIAFLEX for the treatment of Peyronie's disease, an excess of inelastic collagen causing penile curvature