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Pelger-Huët anomaly(pel″gĕr hū′ĕt)
[Karel Pelger, Dutch physician, 1885–1931; Gauthier Jean Huët, Dutch physician, 1879–1970],
A benign autosomal dominant disorder of neutrophil maturation, in which granulocytes form with rodlike, dumbbell, peanut-shaped, and spectacle-like nuclei. The chromatin of the nuclei is unusually coarse. Despite their unusual shape, the oddly formed cells function normally. An anomaly in white blood cell formation called Pseudo-PHA or acquired PHA appears structurally similar to PHA and occurs in myelodysplasia and some leukemias.
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