Pelger-Huët anomaly
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Pelger-Huët anomaly
[pel′gər hyo̅o̅′ət]
Etymology: Karel Pelger, Dutch physician, 1885-1931; G.J. Huët, Dutch physician, 1879-1970; Gk, anomalia, irregular
an inherited disorder characterized by granulocytes with unusually coarse nuclear material and dumbbell-shaped or peanut-shaped nuclei. Normal nuclear segmentation does not occur, but there are no clinical consequences.
Pelger-Huët anomaly
(pel″gĕr hū′ĕt) [Karel Pelger, Dutch physician, 1885–1931; Gauthier Jean Huët, Dutch physician, 1879–1970]
, PHA
A benign autosomal dominant disorder of neutrophil maturation, in which granulocytes form with rodlike, dumbbell, peanut-shaped, and spectacle-like nuclei. The chromatin of the nuclei is unusually coarse. Despite their unusual shape, the oddly formed cells function normally. An anomaly in white blood cell formation called Pseudo-PHA or acquired PHA appears structurally similar to PHA and occurs in myelodysplasia and some leukemias.
Pelger-Huët anomaly
an anomaly, probably inherited, of neutrophils and eosinophils in which there is hyposegmentation of the nuclei. Seen rarely in dogs and cats with no clinical significance.
pseudo-Pelger-Huët anomaly-H. a
a transient hyposegmentation in neutrophils and eosinophils, usually from unknown causes. May be mistaken as the congenital anomaly.