nystatin

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nystatin

 [ni-stat´in]
an antibiotic produced by Streptomyces noursei; used as an antifungal agent in treatment of infections due to Candida albicans and other Candida species; administered orally or topically.

nystatin

Bio-Statin, Candistatin, Dom-Nystatin, Mycostatin, Nadostine, Nilstat, Nyaderm, Nystan (UK), Nystop, Pedi-Dri, PMS-Nystatin, Ratio-Nystatin

Pharmacologic class: Antifungal

Therapeutic class: Anti-infective

Pregnancy risk category A

Action

Interferes with fungal cell-wall synthesis, inhibiting formation of ergo sterols, increasing cell-wall permeability, and causing osmotic instability

Availability

Cream: 100,000 units/g

Ointment: 100,000 units/g

Powder: 100,000 units/g

Suspension: 100,000 units/ml

Tablets: 500,000 units

Troches: 200,000 units

Vaginal tablets: 100,000 units

Indications and dosages

Candidiasis (topical use)

Adults and children: Apply cream, ointment, or powder two or three times daily until healing is complete.

Oral candidiasis

Adults: 400,000 to 600,000 units (suspension) P.O. q.i.d. Have patient gargle and then swallow half of dose in each side of mouth.

Infants: 200,000 units (suspension) P.O. q.i.d. Use half of dose in each side of mouth.

Newborn and premature infants: 100,000 units (suspension) P.O. q.i.d. Use half of dose in each side of mouth.

GI infections

Adults: 500,000 to 1 million units (one to two tablets) P.O. t.i.d. Continue for 48 hours after desired response occurs.

Vaginal candidiasis

Adults: 100,000 units (one vaginal tablet) intravaginally daily for 2 weeks, or 100,000- to 500,000-unit applicatorful (cream) intravaginally once or twice daily for 2 weeks

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:

• renal or hepatic disease, achlorhydria

• pregnant or breastfeeding patients

• children younger than age 2.

Administration

• Give oral suspension by placing half of dose in each side of patient's mouth. Instruct patient to hold suspension in mouth, swish it around, or gargle for several minutes before swallowing it.

• To prepare oral solution from powder, add one-eighth teaspoon to 120 ml of water and stir well. Give immediately.

• Advise patient to let troche dissolve slowly and completely in mouth. Tell her not to chew or swallow it whole.

• Know that nystatin vaginal tablets can be given orally to treat oral candidiasis.

• To apply cream, ointment, or powder, gently and thoroughly massage preparation into skin.

• Use applicator provided for vaginal administration.

Adverse reactions

GI: nausea, vomiting, diarrhea, GI distress, oral irritation

GU: vulvovaginal irritation (with intravaginal form)

Skin: pruritus, rash

Interactions

Drug-drug. Topical corticosteroids: increased corticosteroid absorption

Drug-behaviors. Latex contraceptive use: damage to contraceptive (with intravaginal use)

Patient monitoring

• If patient takes oral tablets, inspect oral mucous membranes for irritation.

• With topical use, monitor affected area for increase in redness, swelling, or irritation.

Patient teaching

• Advise patient to continue taking for at least 48 hours after symptoms resolve.

• Instruct patient to let lozenge dissolve slowly in mouth. Tell her not to chew or swallow it.

• If patient misses a dose, tell her to take dose as soon as possible and then resume her regular dosing schedule.

• Inform patient that diabetes mellitus, reinfection by sexual partner, tight-fitting pantyhose, and use of antibiotics, hormonal contraceptives, or corticosteroids predispose her to vaginal infection. Urge her to wear cotton underwear.

• Tell female patient to practice careful hygiene in affected areas.

• Instruct patient using vaginal tablets to wash applicator thoroughly after each use.

• Tell patient to continue therapy during menstruation.

• As appropriate, review all significant adverse reactions and interactions, especially those related to the drugs and behaviors mentioned above.

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ny·stat·in

(nī-stat'in, nis'tă-tin),
An antibiotic substance isolated from cultures of Streptomyces noursei, effective in the treatment of all forms of candidiasis, particularly candidal infections of the intestine, skin, and mucous membranes.
[New York State + -in]

nystatin

/ny·sta·tin/ (ni-stat´in) an antifungal produced by growth of Streptomyces noursei; used in treatment of infections caused by Candida albicans and other Candida species.

nystatin

(nĭs′tə-tĭn)
n.
An antibiotic, C46H77NO19, produced by the actinomycete Streptomyces noursei and used to treat fungal infections.

nystatin

[nis′tətin]
an antifungal antibiotic.
indications It is prescribed in oral, topical, and vaginal formulations for the treatment of fungal infections of the GI tract, skin, and vagina.
contraindication Known hypersensitivity to this drug is the only contraindication.
adverse effects There are no known serious adverse effects. Mild GI distress and mild skin reactions may occur.

nystatin

Mycostatin Infectious disease An antifungal obtained from Streptomyces noursei, which is effective against oral, GI, and urogenital candidiasis Adverse effects Dysgeusia, N&V, diarrhea, stomach pain.

ny·stat·in

(nī-stat'in)
An antibiotic substance effective in the treatment of all forms of candidiasis, particularly in the intestine, skin, and mucous membranes.
[New York State + -in]

nystatin

A drug used in the treatment of fungus infections, such as thrush (CANDIDIASIS). Nystatin is useful for external infections only as it is not absorbed when given by mouth and is too toxic to be given by injection. The drug is on the WHO official list. A brand name is Nystan. Nystatin is produced in various formulations with other drugs such as NEOMYCIN (Gregoderm), METRONIDAZOLE (Flagyl Compak), TRIAMCINOLONE (Tri-Adcortyl), OXYTETRACYCLINE (Terra-Cortril Nystatin) and the steroid CLOBETASONE (Trimovate).

nystatin

a rod-shaped antibiotic molecule that allows the passage of molecules smaller than 0.4 nm by creating channels through membranes.

nystatin

topical polyene antifungal drug used to treat skin candidal (yeast) infections (see Tinaderm-M)

antifungal agent 

Any substance which destroys or prevents the growth of fungi. It is one of the antibiotic groups. There are several classes of antifungal drugs: Polyenes, which cause an increase in fungal cell wall permeability leading to its death. Examples: amphotericin B, natamycin, nystatin. Azoles, which act either by inhibiting the synthesis of ergosterol, a component of fungal cell wall or by causing direct wall damage. Examples: clotrimazole, econazole, fluconazole, itraconazole, ketoconazole, miconazole. Pyrimidines, which interfere with the normal function of fungal cells. Example: flucytosine. Syn antimycotic agent.

ny·stat·in

(nī-stat'in)
Antibiotic substance isolated from cultures of Streptomyces noursei, effective in treatment of all forms of candidiasis, particularly candidal infections of intestine, skin, and mucous membranes.
[New York State + -in]

nystatin (nis´tətin),

n brand names: Mycostatin, Nystex, O-V Statin;
drug class: antifungal;
action: interferes with fungal DNA replication;
uses: Candida species causing oral, vaginal, and intestinal infections.

nystatin

a polyene antibiotic produced by Streptomyces noursei; used topically in treatment of infections due to Candida albicans, Aspergillus spp., yeasts and some dermatophytes.