peanut allergy


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peanut allergy

Immunology A common cause of anaphylactic reactions which, unlike some allergies, is rarely outgrown; PA is the most common cause of food allergy in the US, and a leading cause of food-induced anaphylaxis and death after accidental exposure

peanut allergy

An IgE-mediated immediate hypersensitivity reaction to the consumption of peanuts (the seeds of Arachis hypogaea). Peanut allergens are designated Ara by the World Health Organization. Peanut allergy is the most important food allergy in the U.S., affecting more than a million people. Reactions range from mild (rashes) to life-threatening (closure of the airway, cardiac dysrhythmias, coma). About 50 people die of peanut allergy in the U.S. each year.

Patient care

People with known allergies to peanuts must avoid eating raw or processed peanuts and also products containing or prepared with peanut oil . Those affected by peanut allergy should learn to watch for the signs of anaphylaxis (hives, pruritus, rashes in the skin creases, shortness of breath, choking, wheezing, stridor). People with known anaphylaxis to peanuts should carry epinephrine injectors and use them at the onset of a hypersensitivity reaction. (Repeated use may be necessary in persistent reactions.) Cross-reactivity to other legumes (peas, soy products) may affect some people and pose important health risks. Affected people should wear medical alert bracelets or necklaces identifying their condition. Densensitization can be accomplished with modified peanut allergens.

See also: allergy

peanut allergy

An often severe form of ALLERGY in which up to one-third of sufferers experience ANAPHYLAXIS. Peanut allergy is not more common than other food allergies, all of which are rare, affecting about 1 person in 100,000 per year. It is becoming commoner, however, and is liable to be more severe than most, and is especially dangerous in asthmatic children. Peanut proteins may be found in such diverse foodstuffs as chocolate spread and scotch eggs. The allergy has been shown to be significantly associated with intake of soy milk or soy formula and with the use of skin preparations containing peanut oil. The increasing incidence is thought to be due to unduly early exposure of babies to peanut butter after weaning.
References in periodicals archive ?
Intrommune's lead product, INT301, is expected to be a safe, effective and convenient therapy for patients who suffer from peanut allergy. There is no FDA-approved treatment for peanut allergy or any other food allergy.
Researchers suggest that in order to prevent peanut allergy, peanut protein (such as peanut butter or powdered puff) may be introduced at home for most babies between 4 and 6 months as one of the first foods.
Gupta also showed that peanut allergy was reported most often among white children (47.7%) and children from households with an annual income of $50,000-$99,999 (41.7%).
Peanut allergy is persistent in the majority of cases, and only outgrown in ~20% of patients.
"Until recently there has been nothing to offer peanut allergy suffers other than education around avoidance and self-treatment of reactions."
Reportedly, ASIT biotech now has three product candidates selected on the ASIT+ platform for allergies with the highest prevalences, namely allergic rhinitis caused by grass pollen, peanut allergy and house dust mite allergy.
A randomized, controlled trial (Learning Early About Peanut Allergy; LEAP, published in 2015) demonstrated that early introduction of peanut-containing food (ie, at 4 months to < 11 months of age) in infants at high risk for peanut allergy (defined as presence of severe atopic dermatitis, egg allergy, or both) resulted in a significantly lower risk of developing peanut allergy by age 60 months compared with peanut avoidance.
THE RESULTS: Children who avoided peanut containing foods had a much higher incidence of having a peanut allergy compared to children who had consistently and frequently consumed peanut products from a young age.
Previous guidelines published in 2010 did not provide specific treatment strategies for peanut allergies because of a lack of research, but the significant results of the Learning Early About Peanut Allergy (LEAP) study suggested that early exposure to peanut-containing foods reduces the risk of developing allergies.
To avoid potentially life-threatening allergic reactions, people with peanut allergy must be vigilant about the foods they eat and the environments they enter, which can be very stressful, said NIAID Director Anthony S.
Global Markets Direct's, 'Peanut Allergy - Pipeline Review, H1 2016', provides an overview of the Peanut Allergy pipeline landscape.
The increase in allergy to peanut in westernised countries [1] has sparked widespread interest in peanut allergy. Recent progress has been made in identifying risk factors for peanut allergy, such as epithelial barrier defects leading to epicutaneous sensitisation by peanut protein.