LAMTOR1

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LAMTOR1

A gene on chromosome 11q13.4 that encodes a regulator of the TOR pathway, a signalling cascade that promotes cell growth in response to growth factors, energy levels and amino acids. As part of the Ragulator complex, LAMTOR1 recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in amino acid activation of the TOR signalling cascade, and anchors the Ragulator complex to membranes. It is required for late endosomes/lysosomes biogenesis and may regulate both endosomal recycling of receptors and MAPK signalling by recruiting some of its components to late endosomes. LAMTOR1 may be involved in cholesterol homeostasis by regulating LDL uptake and cholesterol release from late endosomes/lysosomes. It may also play a role in RHOA activation.
References in periodicals archive ?
Likewise, MDR organisms (meaning resistant to just three classes of antimicrobial agents) are now overshadowed by Carbapenemresistant Enterobacteriaceae (CRE) that can be PDRO (Pan Drug Resistant) meaning resistant to all classes of antibiotics.
The PDRO series of 0.5 to 26.0 GHz phase locked oscillators employ a unique technique to phase-lock microwave DROs to a 5 or 10 MHz crystal reference.
This became a reality in January 2017 when a woman with a PDRO Klebsiella pneumonia contagion that had carbapenem resistance traveled from India to Reno, where she died in a Reno hospital.
Addressing the problem locally--unfortunately the woman with the PDRO from India died but if she survived she would have been a carrier of the pan-resistant Klebsiella and she would have had the ability to cross-contaminate anyone.
Some strains of CRE resistant bacteria are now resistant to all classification groups of antibiotics and these are known as Pan Drug Resistant Organisms, or PDRO.
Looking at the progression of antimicrobial resistance, we have advanced from MultiDrug Resistant Organisms (MDRO) which are resistant to three different classifications of antibiotics, to Extremely Drug Resistant Organisms (XDRO) which are resistant to five or more different classifications of antibiotics, and now on to PDRO's--resistant to all antibiotics.
Well, regrettably in January 2017 the CDC informed us that a second PDRO (Pan Drug Resistant Organism) has been discovered, this time in Reno.
One question I have is how many other PDRO organisms have been discovered that we are yet to learn about?
Antibiotic misuse by patients, inappropriate prescribing practices and historical noncompliance with infection control guidelines have all contributed to the pan drug resistant organisms (PDRO) that we see across our nation today.
If Colistin resistance develops in Nevada's Acinetobacter we now have another PDRO (Pan Drug Resistant Organism) immune to all antibiotics.