SNCA

(redirected from Pd1)
Also found in: Acronyms.

SNCA

A gene on chromosome 4q21 that encodes alpha synuclein, which may be involved in regulating dopamine release and transport. SNCA induces fibrillisation of microtubule-associated protein tau, reduces neuronal responsiveness to apoptotic stimuli, and downregulates caspase-3.
References in periodicals archive ?
The team combined the vaccine ISA101, which targets important peptides produced by the strongly cancer-promoting HPV16 genotype of the virus, along with nivolumab, a checkpoint inhibitor that blocks activation of PD1 on T cells.
The binding of IFN[alpha] to IFNAR1/IFNAR1 leads to the formation of ISGF3 (a heterotrimer of STAT1, STAT2, and IRF9) which can upregulate the expression of PD1 and IRF7.
A recommended approach is to perform a diligent low- and high-power morphologic evaluation of the lymph node to search for malignant lymphocytes, with judicious use of immunohistochemical stains for CD45, CD3, CD20, PAX5, OCT-2, BOB.1, CD30, CD15, EMA, IgD, CD57, PD1, and CD21.
* The report provides a snapshot of the global therapeutic landscape for Programmed Cell Death Protein 1 (CD279 or Systemic Lupus Erythematosus Susceptibility 2 or PD1)
Analysis of the frequency of TREG-I ([CD25.sup.+] CD127low/0Fox[P3.sup.+]) and TREG-II ([CD25.sup.high]CD127low/0Fox[P3.sup.+]) cells expressing OX40 (A), PD1 (B), and GITR (C) in patients with active SLE (A-SLE), inactive SLE (I-SLE), and healthy controls (HC).
In addition, low levels of PD1 in the lungs of influenza-virus- infected mice were associated with severe infection and highly pathogenic viruses, such as H5N1.Treatment with PD1 in combination with an approved antiviral drug improved the survival of influenza-virus-infected mice and prevented death, even when given two days after infection.
But I could not resist taking this snap alongside the Birkenhead Corporation Transport 1946 Leyland derivative, with a PD1 chassis and fitted with a Mitilda MK 2 Tank engine left over from making tanks in the war years.
The 10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z- docosahexaenoic acid (PD1 or protectin D1) standard was kindly provided as a gift by Professor Charles N.
The PD1 Vibro finishing machines--an 'EVT 600' vibratory trough, a '1VP 400' centreless bowl and an 'EVP 550 plain bowl--form an integral part of the C.A.S.E process and have been supplied to MIC, Derby, as part of a "Partnered Support" alliance, through which PDJ Vibro provides an ongoing technical and maintenance service to ensure that its machines operate at optimum performance throughout their working life.
Table 3 The considered periods, number of observations, and notation of samples Frequency of data daily weekly monthly sample period A B A B A B Whole 03.01.2000-27.03.2009 PD0 2377 PW0 482 PM0 110 Bear Market1 03.01.2000-08.10.2001 PD1 455 PW1 92 - - Stagnation 09.10.2001-03.07.2003 PD2 445 PW2 90 - - Bull Market1 04.07.2003-27.10.2005 PD3 600 PW3 121 - - Bull Market2 28.10.2005-06.07.2007 PD4 434 PW4 89 - - Bear Market2 09.07.2007-27.03.2009 PD5 443 PW5 90 - - Own calculation.