PCSK1

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PCSK1

A gene on chromosome 5q15-q21 that encodes a peptidase S8 family convertase involved in processing pairs of basic amino acid residues located on prohormones and other protein precursors (e.g., POMC, renin, enkephalin, dynorphin, somatostatin and insulin).

Molecular pathology
Defects in PCSK1 cause proprotein convertase 1 deficiency.
References in periodicals archive ?
Sensitivity to irradiation of PC3 and LNCaP cells was reduced by HULC
Furthermore, the first (PC1 x PC2) and second Cartesian planes (PC1 x PC3), which described the variability of the data in further detail (63.68% and 56.36%, respectively), enabled the placement of the clusters in relation to the different quality parameters of the milk.
A specific number of cells (for HN5, 5 x [10.sup.3] cells/well; for Hs-680Tg, 8 x [10.sup.3] cells/well; and for PC3, 1 x [10.sup.4] cells/well, all cells in 100 [micro]L culture medium) were plated in clear 96-well cell-culture plates overnight and then cells were treated with the greatest clinical exposure concentration (i.e., if 120 markers [the maximum number likely to be used in one patient with a prostate volume of 60 cc] were to leak simultaneously into the human periprostatic area after implantation) of C4 or its components (1% Co[Cl.sub.2] x 6[H.sub.2]O, or the 2% NAC, or the Co:NAC [1%:2%]), and cells were incubated at 37[degrees]C.
Briefly, PC3, MDA, WM9, BPH1, K562, and HEL cells were seeded in 96-well microculture plates at the density of 5 x [10.sup.3] cells/well and incubated for 24 h to allow cell adhesion.
The human prostate androgen-independent PC3 cell line was obtained by ATCC.
In HKI1532, 73% DEGs were assigned to at least one of the three Gene Ontology (GO) terms, namely, biological process, cellular component, and molecular function; in PC3, corresponding figure was 72%.
The present flow cytometric analysis in PC3 cells demonstrated that the number of cells in G0/G1 was significantly increased and cells in G2/M were decreased after the treatment of EAESI.
PC3 and PC4 indicate relatively more local or specific effects such as the dissolution of fluorite and carbonate balance.
The present study deals with the synthesis of various benzophenone-bis-Schiff bases and their cytotoxic effect on PC3 human pancreatic cancer cell line.
Third principal component (PC3) wascorrelated with three of the original variables.andincreased with the increase in leaf color (LC,0.163), leaf shape (LSH,0.256) and presence of fiber (FBR,0.233) while it was highly correlated with FBR (0.233).The conclusion of present study are in accordance with those of Malik et.al.,(2012) and Shrestha et.al.,(2012) who narrated that fruit weight, fruit length, fruit diameter, fruit rind thickness, TSS, leaf length and leaf width as important variables with the highest provenance to the variation contributed by the principal components.
These conditioned media, minus the ASCs, were then used to culture PC3 cells.
The new components are called PC1, PC2, PC3 and so on, (for the first, second and third principal components) are independent and decrease the amount of variance from the original data set.