Paxil CR is the controlled-release formulation of the popular anti-depressant drug Paxil, and Avandamet is a combination of Avandia and metformin.
Antidepressants Wellbutrin XL and
Paxil CR, the Imitrex migraine pill, epilepsy drug Lamictal and Requip for restless legs all faced generic rivals in the U.S.
GlaxoSmithKline, which markets
Paxil CR, supplied the drug used in this study, but otherwise the study and investigators received no industry support.
Glaxo was allowed to reintroduce
Paxil CR and another drug - its Avandamet diabetes treatment - after it identified the source of manufacturing problems and took corrective action.
The company's stock fell sharply in March when the Food and Drug Administration (FDA) forced it to withdraw antidepressant
Paxil CR and its Avandamet diabetes treatment amid concerns they were of poor quality.
To date, the changes have been made to the labels for paroxetine (Paxil,
Paxil CR).
To date, the changes have been made to the labels for paroxetine (Paxil,
Paxil CR), citalopram (Celexa), fluvoxamine (Luvox), and venlafaxine and venlafaxine ER (Effexor).
SkyePharma has a partnership with GlaxoSmithKline for marketing depression drug
Paxil CR and is developing new versions of drugs including AstraZeneca's Pulmicort and GlaxoSmithKline's Requip.
The drugs, manufactured in Puerto Rico between 2001 and 2005, included the antinausea drug Kytril, the antidepressant
Paxil CR, the diabetes medication Avandamet, and the anti-infection ointment Bactroban.
The procedures were implemented as part of a consent decree with the FDA that was signed last year by GSK after the company was cited for manufacturing deficiencies associated with
Paxil CR (paroxetine) and Avandamet (rosiglitazone and metformin), which are produced at the same Cidra, Puerto Rico, manufacturing facility that makes Coreg.
He and his associates analyzed blinded pharmacy records from 1,157 pharmacies across the country to find patients who filled prescriptions for fluoxetine, sertraline (Zoloft), paroxetine (
Paxil CR), venlafaxine (Effexor XR), citalopram (Celexa), or escitalopram (Lexapro).
Glaxo, which employs 2,200 people at Barnard Castle in County Durham and Ulverston in Cumbria, said sales in the US would have grown 7% from April to June rather than 3% had federal authorities not forced it to halt supplies of
Paxil CR last March.