paroxetine

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paroxetine

[pah-rok´sĕ-tēn]

a selective serotonin reuptake inhibitor administered orally as the hydrochloride salt as an antidepressant and to treat obsessive-compulsive, panic, and social anxiety disorders.

paroxetine

/par·ox·e·tine/ (pah-rok´sĕ-tēn) a selective serotonin uptake inhibitor used as the hydrochloride salt to treat depression and obsessive-compulsive, panic, and social anxiety disorders.

paroxetine

(pă-rŏk′sĭ-tēn′)

A drug of the SSRI class, C₁₉H₂₀FNO₃, used in its hydrochloride form to treat depression, anxiety, and certain other disorders, including obsessive-compulsive disorder.

paroxetine

a selective serotonin reuptake inhibitor.

indications It is prescribed in the treatment of mental depression, obsessive-compulsive disorder, panic disorders, and anxiety disorders, including social anxiety and general anxiety. Unlabeled uses include treatment of impulse control disorders, premenstrual syndrome, and vasomotor symptoms of menopause.

contraindications It should not be given to patients taking monoamine oxidase inhibitors. Caution is advised in administering the drug to patients with a history of drug abuse, mania, seizures, suicidal tendencies, or kidney or liver disease.

adverse effects The side effects most often reported include decreased libido and ejaculatory disturbances, nausea, diarrhea, vomiting, constipation, abdominal pain, flatulence, changes in appetite, and muscle weakness. Paroxetine may also cause SIADH and/or hyponatremia and lead to or exacerbate coagulation disturbances because of impairment of platelet aggregation.

paroxetine

A SEROTONIN RE-UPTAKE INHIBITOR drug. A brand name is Seroxat.

References in periodicals archive ?

Antidepressants Wellbutrin XL and Paxil CR, the Imitrex migraine pill, epilepsy drug Lamictal and Requip for restless legs all faced generic rivals in the U.

Glaxo first-quarter hit by generics in US market

Glaxo was allowed to reintroduce Paxil CR and another drug - its Avandamet diabetes treatment - after it identified the source of manufacturing problems and took corrective action.

Blue-chip results to be in the spotlight

The delays are also affecting Paxil CR and Avandamet supplies, but a "Dear Healthcare Professional" letter was not issued in regard to these drugs, because unlike severe heart failure patients and patients with post-myocardial infarction left ventricular dysfunction, patients on these drugs have alternative treatment options and are not generally considered to have life-threatening illness, she explained.

Carvedilol shortage temporary, emergency shipments available

Glaxo, which employs 2,200 people at Barnard Castle in County Durham and Ulverston in Cumbria, said sales in the US would have grown 7% from April to June rather than 3% had federal authorities not forced it to halt supplies of Paxil CR last March.

Dispute hit GSK sales growth in US

The firm recently re-introduced antidepressant Paxil CR after it was withdrawn amid fears over its quality, but analyst Jeremy Batstone at stockbroker Charles Stanley said its return came too late to affect Thursday's interim results.

A week of testing times ahead for investors

Glaxo is expected to meet the Food and Drug Administration (FDA) within weeks to resolve issues that led US regulators to enforce the withdrawal of antidepressant Paxil CR and its Avandamet diabetes treatment.

Fear over Glaxo profits

8 million settlement will include any individuals in the United States who bought Paxil or Paxil CR for their minor children.

Paxil settlement

The group's second quarter earnings are expected to be almost unchanged from those of the same period last year, due to the suspension of the production of its diabetes treatment, Avandamet, and its antidepressant, Paxil CR.

GSK shares close 7p higher

Mylan has rolled out its copy of Paxil CR, an antidepressant.

Requip now has generic competitors

The success of Advair, its asthma treatment drug, is expected to offset any negative impact on the results from sales of Paxil CR and Wellbutrin, which have been affected by generic competition.