pattern recognition receptor

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pattern recognition receptor

Abbreviation: PRR
A receptor on an antigen-presenting cell of the immune system that recognizes molecular sequences found on disease-causing organisms but not host cells. PRRs detect the presence of pathogen-associated chemicals such as lipopolysaccharides, mannans, and teichoic acids.
See also: receptor
References in periodicals archive ?
Inflammatory caspases are activated within so-called inflammasomes, Cytosolic signalling platforms that are assembled by pattern recognition receptors upon the detection of pathogen- or host-derived danger signals.
3] The activation of pattern recognition receptors by PAMPs and DAMPs leads to activation of specific inflammatory response by 'inflammasome' complex.
17) One of the emerging concepts in immunology as applied to the development of ARDS is pattern recognition receptors (PRRs)--critical components of the innate immune system that serve as a "first line of defense.
It is thought that innate immunity gene expression is disrupted in the epithelium of patients with chronic rhinosinusitis (CRS), including antimicrobial peptides and pattern recognition receptors (PRRs).
parenchymal cells) in most organs; however, activation of pattern recognition receptors triggers proinflammatory cytokine induction most robustly in the immune cells.
It relies on pattern recognition receptors on innate immune cells to detect evolutionarily conserved pathogen-associated molecular patterns expressed on pathogen surfaces.
They discuss the cell types that produce the innate immune system, their use of pattern recognition receptors to identify pathogens and damaged tissues, and how they trigger signaling pathways that cause inflammation, pathogen destruction, and tissue repair, as well as the chemical signals and factors involved in innate immunity, inflammation, and its prevention.
Notwithstanding the involvement of epithelial pattern recognition receptors in triggering protective inflammatory responses, the epithelium functions as both a barrier and hostile environment.
More recently toll like receptors (TLRs), the pattern recognition receptors that regulate innate immunity and microbial tolerance, have been shown to be dysregulated in IBS.
Insulin appears to suppress a particular group of inflammatory mediators known as toll-like receptors, or TLRs, which are a variety of pattern recognition receptors that identify bacterial and viral products and other pathogens.
It acts through a variety of primitive and more advanced mechanisms, including the complement cascade, pattern recognition receptors, and macrophages to identify and target foreign intruders.

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