androgenetic alopecia

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alopecia

 [al″o-pe´shah]
loss of hair; baldness. The cause of simple baldness is not yet fully understood, although it is known that the tendency to become bald is limited almost entirely to males, runs in certain families, and is more common in certain racial groups than in others. Baldness is often associated with aging, but it can occur in younger men. minoxidil has been approved as a topical treatment for male pattern baldness. Approximately one-third of the men undergoing this therapy have experienced hair regrowth. The effects of the drug take several months to develop and new hair growth may be limited; the hair is lost if treatment is discontinued. Hair transplants are also available to selected patients. Many men opt for no treatment.

Alopecia as an outcome of chemotherapy for a malignancy can be very distressing. The loss of hair usually is temporary and the hair will grow back after the course of treatment is completed. Male patients may feel more comfortable wearing a hat or cap when out in public. Female patients who wish to wear a wig are encouraged to obtain one that is lightweight and the same color as their hair. Having a hairdresser cut the wig to the patient's usual hair style can increase self-esteem. A kerchief or head scarf can be worn around the house if it is more comfortable than a wig. Receipts for wigs, hairpieces, and other headcovering should be saved; they are tax-deductible medical expenses when related to chemotherapy.
androgenetic alopecia (alopecia androgene´tica) a progressive, diffuse, symmetric loss of scalp hair. In men it begins in the twenties or early thirties with hair loss from the crown and the frontal and temple regions, ultimately leaving only a sparse peripheral rim of scalp hair (male pattern alopecia or male pattern baldness). In females it begins later, with less severe hair loss in the front area of the scalp. In affected areas, the follicles produce finer and lighter terminal hairs until terminal hair production ceases, with lengthening of the anagen phase and shortening of the telogen phase of hair growth. The cause is unknown but is believed to be a combination of genetic factors and increased response of hair follicles to androgens.
alopecia area´ta hair loss in sharply defined areas, usually the scalp or beard.
alopecia ca´pitis tota´lis loss of all the hair from the scalp.
cicatricial alopecia (alopecia cicatrisa´ta) irreversible loss of hair associated with scarring, usually on the scalp.
congenital alopecia (alopecia congenita´lis) congenital absence of the scalp hair, which may occur alone or be part of a more widespread disorder.
alopecia limina´ris hair loss at the hairline along the front and back edges of the scalp.
male pattern alopecia see androgenetic a.
moth-eaten alopecia syphilitic alopecia involving the scalp and beard and occurring in small, irregular scattered patches, resulting in a moth-eaten appearance.
symptomatic alopecia (alopecia symptoma´tica) loss of hair due to systemic or psychogenic causes, such as general ill health, infections of the scalp or skin, nervousness, or a specific disease such as typhoid fever, or to stress. The hair may fall out in patches, or there may be diffuse loss of hair instead of complete baldness in one area.
alopecia tota´lis loss of hair from the entire scalp.
alopecia universa´lis loss of hair from the entire body.

androgenetic alopecia

(ăn′drō-jə-nĕt′ĭk)
n.
Progressive loss of scalp hair associated with increased sensitivity of hair follicles to androgens, thought to be caused by both genetic and environmental factors. It is more common and more severe in men (where it is referred to as "male pattern baldness" or "male pattern hair loss") than in women ("female pattern baldness" or "female pattern hair loss").

androgenetic alopecia

Hereditary thinning of hair induced by androgens in genetically susceptible men and women, which occurs in ± 50% of the general population between age 12 and 40.
 
Mechanism
Dihydrotestosterone binds to androgen receptors of susceptible scalp hair follicles, activating genes that gradually transform large terminal hair follicles to miniature follicles, producing finer hair in shorter hair cycles. Dihydrotestosterone is formed by peripheral conversion of testosterone by one of two isoforms of 5α-reductase, which, with other enzymes, regulate specific steroid transformations in skin. Those with AA have increased 5α-reductase, increased androgen receptors and decreased cytochrome P-450 aromatase, which converts testosterone to estradiol in hair follicles in the frontal scalp.
 
Management
Finasteride, minoxidil.

Androgenetic alopecia

Hair loss that develops into baldness and affects both men and women.
Mentioned in: Minoxidil

Patient discussion about androgenetic alopecia

Q. Do you know if Propecia can truly stop hair loss and even grow back hair. do you have any statistics about it? do you know if there are any side effects to this medication?

A. it does work but there is some side affects, as in E.D. while you are on the med.

More discussions about androgenetic alopecia
References in periodicals archive ?
The researchers trawled the Medline and the Cochrane Library databases for research published on male pattern baldness and coronary heart disease, and came up with 850 possible studies, published between 1950 and 2012.
"It is the first signs of the male pattern baldness which has affected both his brother and his father," he said.
Kathryn, Cumbria AMALE pattern baldness, which is the leading cause of hair loss in men, can start at any age from as early as the late teens.
Drugs that block activity of the protein could provide effective treatments for male pattern baldness.
However, she added that this only solves part of the puzzle: "It is important to note that while these two conditions share the same physiologic process, the gene we found for hereditary hypotrichosis does not explain the complex process of male pattern baldness."
Genetics are behind the most common form of hair loss, androgenetic alopecia (male pattern baldness), in which the hair cycle shortens, the hair follicles thin and more hairs remain in the telogen phase.
Taking a tablet called Propecia will prevent hair follicle shrinkage and is said to have helped in 30 per cent of cases of male pattern baldness. Ask your GP for more information.
A link exists between the lack of oxygen in the cells of the scalp and male pattern baldness, according to a study by plastic surgeon Steven L.
Smart, a toxicologist at North Carolina State University in Raleigh who led the study, these findings may suggest new therapies for a range of conditions, from hair loss due to chemotherapy or male pattern baldness to the excessive growth of unwanted hair on women.
Even if you have lost your hair or it is thinning or receding, or you have pattern baldness or alopecia.
AMALE pattern baldness, as it is known, is due to the hair follicles being sensitive to circulating testosterone, the male hormone responsible for, amongst other things, the sex drive.
The treatment only works for patients with male pattern baldness and not other types of hair loss.