Contract award: delivery amplifiers, transmitters and software for measurement using patch clamp
, amikroskopu - part 4: an inverted microscope with fluorescence.
In its GLP-compliant laboratories, Southern Research recently implemented an in vitro screening program on CytoPatch(TM) C the automated patch clamp
platform C and successfully demonstrated in vitro hERG ion channel blocking by drug candidates.
Qube is a 384-channel automatic patch clamp
system that delivers ion channel data at an unprecedented throughput.
2+] currents was studied on single colonic smooth muscle cells using the patch clamp
com)-- Graeme Daniels, Sales Director at Cytocentrics, said “We are extremely happy to have found a company of SciPro's calibre to work with to bring our new CytoPatch2 automated patch clamp
system to the North American market.
Measurement of cellular excitability by whole cell patch clamp
In contrast to single-cell, acute techniques like patch clamp
, the xCELLigence system provides real-time, label-free beating pattern analysis and is used in a fully controlled environment (within a tissue culture incubator) for continuous short-term and long-term experiments, allowing for more physiologically relevant data.
Bert Sakmann and Erwin Neher performed the first patch clamp
single-channel recordings in 1976, for which they were awarded the Nobel Prize in 1991.
In general, patch clamp
recordings from membrane patches containing multiple channels exhibit an independent gating behavior consistent with binomial probability distribution.
Budipine is a low affinity, N-methyl-D-aspartate receptor antagonist: Patch clamp
studies in cultured striatal, hippocampal, cortical and superior colliculus neurones.
Products include the BioFlux(TM) System for studying cellular interactions, the IonFlux(TM) System for high throughput patch clamp
measurements, and the IsoFlux(TM) System for circulating tumor cells.
Measuring ionic current through the channels requires a patch clamp
system sensitive enough to record a small signal-on the order of pico to nano amps (10[sup.