PARK2

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Related to Parkin: Parkinson's disease

PARK2

A gene on chromosome 6q25.2-q27 that encodes a protein that functions within a multiprotein E3 ubiquitin ligase complex, catalysing the covalent attachment of ubiquitin moieties onto substrate proteins—e.g., BCL2, SYT11, CCNE1, GPR37, STUB1, SEPT5, ZNF746 and AIMP2. It also participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating polyubiquitination of misfolded proteins. PARK2 may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis; it may have tumour suppressor activity.
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Parkin eventually fled with a National Lottery terminal from the counter but was soon traced and arrested.
Parkin was jailed for a minimum of 23 years after he admitted stabbing Julie Parkin to death when she discovered he had indecent images of a child.
Prosecutor David Baird told Southwark crown court: "It was thought initially they were builders." Parkin and two others were allegedly caught with 6.8 litres of "liquid ecstasy" GBL, which is popular in the gay chemsex scene.
After a blind taste test, reporters Andrew Robinson and Susie Beever were in agreement which parkin was the best.
Parkin levelled from close range seven minutes later after the Cheltenham defence failed to deal with a corner.
The joint committee has offered approval for a $3.358 million worth of budget for the next year for the Parkin Properties of Wallbridge, situated north of Capreol.
She told him her age -but it didn't stop Parkin committing the sickening crimes.
Parkin and dynamin-related protein 1 (Drp1) play a pivotal role in mitochondrial fission and clearance [3].
WHEN 'The Beast' speaks, people listen and former Cardiff City striker Jon Parkin has typically pulled no punches as he reflected on his time with the Bluebirds.
WHEN 'The Beast' speaks, people listen and former Cardiff City strik-ker Jon Parkin has typically pulled no punches as he reflected on his time with the Bluebirds.
Ming Guo, the study team leader, associate professor of neurology and pharmacology and a practicing neurologist at UCLA was one of two groups worldwide that first reported in 2006 in the journal Nature that two of these genes, PTEN-induced putative kinase 1 (PINK1) and PARKIN, act together to maintain the health of mitochondria - the power house of the cell that is important in maintaining brain health.