pargyline


Also found in: Dictionary, Wikipedia.

pargyline

Eutonyl Pharmacology An MAOI with antidepressant activity; it is less effective than TCAs; it requires abstinence from foods with tyramine; interacts metabolically with other drugs; its use is limited to Pts unresponsive to TCAs and tetracyclic antidepressants and Pts with atypical depression. See Monoamine oxidase inhibitor, Tricyclic antidepressants.

pargyline

a monoamine oxidase inhibitor, used as the hydrochloride salt.
References in periodicals archive ?
MAO-dependent oxidation was defined as sensitive to inhibition by 1 mM pargyline, whereas SSAO-dependent oxidation was abolished by 1 mM semicarbazide.
It was tested whether the response to tyramine was sensitive to reference inhibitors: pargyline (MAO-selective) and semicarbazide (SSAO-selective).
Again, the combination of pargyline and semicarbazide did not inhibit further than the SSAO inhibitor semicarbazide alone, leaving unaltered 20% proportion of the signal.
Figure 5 shows that pargyline inhibited the MAO-dependent [[sup.
The addition of both pargyline and semicarbazide could not inhibit further than semicarbazide alone, which eradicated the generation of labelled benzaldehyde.
Indeed, semicarbazide, together with pargyline, did not modify basal or insulin-stimulated glucose uptake, while it clearly inhibited benzylamine action (Figure 9).
3]H]dopamine was used as trace with unlabeled dopamine) and 1 [micro]M pargyline (to prevent dopamine metabolization by MAO).
Previously, we were able to establish the possibility of artificially creating protracted depressive states in experimental animals by the induction of auto-antibodies to the psycho-stimulant with antidepressive effects sydnophen, as well as to exogenous inhibitors of monoamine oxidase (MAO), antidepressants, pargyline, and deprenyl (Ashmarin, Danilova, Mashkovskii, et al.
Immunization was accompanied by the formation of antibodies to pargyline or deprenyl, increased activity of MAO, and changes in the concentration of biogenic amines.
On the other hand, induction of protracted depression by immunization with MAO inhibitors pargyline, deprenyl and in particular, isatin, is of interest for the treatment of maniacal and aggressive states.
Pargyline conjugate-induced long-term activation of monoamine oxidase as an immunological model for depression.
An open trial of pargyline in the treatment of attention deficit disorder, residual type.