paratope


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Related to paratope: agretope, Idiotope

determinant

 [de-ter´mĭ-nant]
a factor that establishes the nature of an entity or event.
antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has several or many different antigenic determinants and reacts with many different antibodies. Called also epitope.
 Antigens contain antigenic determinants (epitopes) and antibodies contain antibody combining sites (paratopes). From Copstead and Banasik, 2000.
hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
immunogenic determinant the part of an immunogenic molecule that interacts with a helper T cell in triggering antibody production as opposed to the antigenic determinant or hapten, which interacts with B cells.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

par·a·tope

(par'ă-tōp),
That part of an antibody molecule composed of the variable regions of both the light and heavy chains that combine with the antigen.
[para- + -tope]
Farlex Partner Medical Dictionary © Farlex 2012

par·a·tope

(par'ă-tōp)
That part of an antibody molecule composed of the variable regions of both the light and heavy chains that combine with the antigen.
Synonym(s): antibody-combining site.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
In this study, we isolated peptides binding specifically with the paratope regions of six PSA MAbs and studied their reactivity with a large panel of PSA antibodies.
As hypothesized in our last report (9), we assume that such a cross-link would occur between some part of E2 outside of the epitope structure and some part of the anti-E2 antibody outside the paratope structure, such as the sidechains of amino acids.
BsMAbs are uniquely engineered antibodies bearing two different binding sites (paratopes) in a single antibody molecule, in contrast with the monospecific antibodies that possess two congruous paratopes [16,17].
Artificial immune network model is based on the theory of immune network, which states that the immune cells act as a mutually reinforcing network constructed by the matching between paratopes and idiotopes of antibodies.
Preparation and study of properties of anti-idiotypic antibodies, carrying hemagglutinating paratopes of tickborne encephalitis virus on their surface [in Russian].