paraprotein

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paraprotein

 [par″ah-pro´tēn]
a normal or abnormal plasma protein appearing in large quantities as a result of some pathologic condition, now replaced in most contexts by the term m component.

par·a·pro·tein

(par'ă-prō'tēn),
1. A monoclonal immunoglobulin of blood plasma, observed electrophoretically as an intense band in γ, β, or α regions, due to an isolated increase in a single immunoglobulin type as a result of a clone of plasma cells arising from the abnormal rapid multiplication of a single cell. The finding of a paraprotein in a patient's serum indicates the presence of a proliferating clone of immunoglobulin-producing cells and may be seen in a variety of malignant, benign, or nonneoplastic diseases.
[para + protein, fr. G. protos, first]

M spike

A term of art referring to a zone of increased concentration of a monoclonal immunoglobulin when seen by serum electrophoresis.

par·a·pro·tein

(par'ă-prō'tēn)
1. A monoclonal immunoglobulin of the blood plasma, produced by a clone of plasma cells arising from the abnormal rapid multiplication of a single cell. Paraprotein in serum may be seen in various malignant, benign, or nonneoplastic diseases.
2. Synonym(s): monoclonal immunoglobulin.
[para + protein, fr. G. protos, first]

paraprotein

An abnormal plasma protein such as the MONOCLONAL immunoglobulin in MYELOMATOSIS.

Paraprotein

M-protein; abnormal immunoglobulin produced in multiple myeloma.
Mentioned in: Multiple Myeloma
References in periodicals archive ?
No paraproteins were detected, but the kappa/lambda ratio was 1.69 (n: 0.26-1.65).
TPE removes monoclonal antibiotics, paraproteins, autoimmune antibodies and antigen-antibody complexes.
Performance of the Sebia CAPILLARYS 2 for detection and immunotyping of serum monoclonal paraproteins. Am J Clin Pathol.
Serum protein and immunofixation electrophoreses did not show paraproteins. Urinalysis showed 3-5 WBC/ high-power field (hpf), 50-100 RBC/hpf, and 2+ proteins.
In the HIV-negative group, immunoglobulin G (IgG) and IgA paraproteins and myeloma light-chain disease were mainly seen, while in the HIV-positive group only IgG paraproteins were found (Table 5).
* For Total Immunoglobulins (IgG, M, A), IgG and IgA subclasses, Paraproteins and Functional Immunoglobulins
Very low or undetectable HDL-C more often originates from assay interference from paraproteins and autoantibodies or secondary to the use of drugs, including anabolic steroids and fibrates.
In MGUS, as in our patient, paraproteins bind to vWF resulting in accelerated clearance and low circulating levels [2].
The main clinical features are lytic lesions caused by local growth of malignant plasma cells in bones and renal insufficiency due to deposition of paraproteins produced by myeloma cells [24].
Monoclonal gammopathy of undetermined significance and other entities associated with monoclonal paraproteins
Based on these results, the authors considered 2D-gel electrophoresis has higher sensitivity and resolution of the IgD paraproteins than the conventional gel electrophoresis (14).
(7) However, with the use of serum free light chain (FLC) assays, monoclonal FLC appear to be the most commonly detected paraproteins in CLL.