Management of complicated parapneumonic effusions
and thoracic empyema.
The CK19 analysis helped us to exclude adenocarcinomas versus tuberculosis, transudates, and parapneumonic effusions
with a highly significant P value (Dunn's test, P < 0.0001), as shown in Table 2.
[1,34,35] Drainage is the mainstay of initial treatment of complex parapneumonic effusions
Light, "Parapneumonic effusions
and empyema," Proceedings of the American Thoracic Society, vol.
All TA activation-positive patients had complicated pneumonia with parapneumonic effusions
, empyema, necrotizing pneumonia, and/or lung abscesses, as did 36% of the negative group.
Lung Therapeutics has designed LTI-01 to treat empyema and Complicated Parapneumonic Effusions
, two complications of pneumonia that can involve fibrinous scarring that inhibits fluid drainage.
The authors detected Streptococcus pneumoniae in 66% of parapneumonic effusions
Immediate drainage is not required for all patients with complicated parapneumonic effusions
. Chest J.
However, high FADA levels can also occur in other disease conditions and particularly in empyemas, lymphomas, carcinomas and parapneumonic effusions
due to proliferation of large numbers of neutrophils and lymphocytes in these conditions, resulting in false-positive results and misdiagnosis.
usually carry a good outcome with therapeutic interventions.
Causes of an exudate Frequent * Tuberculosis * Malignancy * Parapneumonic effusions
Infrequent * Rheumatoid and other autoimmune disorders * Post-myocardial infarct syndrome * Post-coronary artery bypass * Asbestos-related effusion * Pancreatitis * Drugs (Table 3) Clinical presentation