paraoxonase


Also found in: Acronyms.

paraoxonase

(par-ă-oks'ŏ-nās),
A high-density-lipoprotein-associated enzyme capable of hydrolyzing lipid peroxides, with a known polymorphism; aryldialkylphosphatase, E.C.3.1.8.1. Two isoforms occur: A isoform, with glutamine at position 192; B isoform, with arginine at position 192.
References in periodicals archive ?
They found significantly reduced levels of paraoxonase activity among current smokers and ex-smokers who had stopped for less than three months.
Association of serum paraoxonase activity and coronary artery calcification.
The main anthropometric and biochemical serum parameters, including the levels of markers of oxidative damage to lipids (hydroperoxides) and proteins (AOPP), ceruloplasmin, Lp-PLA2, and paraoxonase as well as TRAIL serum levels of the cohort of subjects (78% women) enrolled in the present study, are summarized in Table 1.
Genetic variations of the paraoxonase gene in patients with coronary artery disease.
Abbreviations Compound V: Sodium (2,2'-bipyridine)oxidobisper- oxidovanadate(V) octahydrate, Na[VO[([O.sub.2]).sub.2](2,2'-bpy)] x 8[H.sub.2]O Compound B: Bis(2,2'-bipyridine)oxidovanadium(IV) sulfate dihydrate, [VO(S[O.sub.4])(2,2'-bpy)] x 2[H.sub.2]O Compound Bm: Bis(4,4'-dimethyl-2,2'- bipyridine)oxidovanadium(IV) sulfate dihydrate, [VO[(4,4'-Me-2,2'-bpy).sub.2]]S[O.sub.4] x 2[H.sub.2]O GLUT-4: Glucose transporter type 4 TCHOL: Total cholesterol TG: Triglycerides HDL: High density lipoprotein PON1: Paraoxonase 1.
The arylesterase and paraoxonase activities of PON1 were measured spectrophotometrically using the substrates phenylacetate and paraoxon (O, O-diethyl O-(4-nitrophenyl) phosphate), respectively [23].
Paraoxonase (PON) is a HDL-associated enzyme and a family of [Ca.sup.2+] depended hydrolase that inhibits low-density lipoprotein oxidation.
This study measured paraoxonase (PON) and arylesterase (ARE) activities as antioxidants, and the level of malondialdehyde (MDA), an end product of lipid peroxidation and the level of zinc which is a trace element acting as antioxidant in children with TIDM and also healthy control subjects.
[16] studied the levels of the antioxidant paraoxonase in patients with BPPV before and after treatment and reported results similar to ours.