paraneoplastic syndrome

(redirected from Paraneoplastic phenomenon)

paraneoplastic syndrome

 [par″ah-ne″o-plas´tik]
a collective term for disorders arising from metabolic effects of cancer on tissues remote from the tumor; such disorders may, for example, appear as primary endocrine, hematologic, or neuromuscular disorders.

par·a·ne·o·plas·tic syn·drome

a syndrome directly resulting from a malignant neoplasm, but not resulting from the presence of tumor cells in the affected parts.

paraneoplastic syndrome

Oncology A co-morbid condition due to the indirect–remote or 'biologic' effects of malignancy, which may be the first sign of a neoplasm or its recurrence; PSs occur in > 15% of CAs, are caused by hormones, growth factors, biological response modifiers, and other as-yet unidentified factors, and may regress with treatment of the primary tumor. See Ectopic hormone.
Paraneoplastic syndromes
GI tract, eg anorexia, vomiting, protein-losing enteropathy, liver disease
Hematologic, eg leukemoid reaction, reactive eosinophilia, peripheral 'cytoses or 'cytopenias, hemolysis, DIC, thromboembolism, thrombophlebitis migrans
Hormonal effects
Metabolic disease, eg lactic acidosis, hypertrophic pulmonary osteoarthropathy, hyperamylasemia, hyperlipidemia
Neuromuscular, eg peripheral neuropathy, myopathy, CNS, spinal cord degeneration, inflammation
Renal, eg nephrotic syndrome, uric acid nephropathy
Skin, eg bullous mucocutaneous lesions, acquired ichthyosis, acanthosis nigricans, dermatomyositis
Others, eg callus formation, hypertension, and amyloidosis

par·a·ne·o·plas·tic syn·drome

(par'ă-nē-ō-plas'tik sin'drōm)
A syndrome directly resulting from a malignant neoplasm, but not resulting from the presence of tumor cells in the affected parts.

Paraneoplastic syndrome

A set of symptoms that is associated with cancer but is not directly caused by the cancer.
Mentioned in: Thymoma

par·a·ne·o·plas·tic syn·drome

(par'ă-nē-ō-plas'tik sin'drōm)
Syndrome directly resulting from a malignant neoplasm, but not resulting from presence of tumor cells.

paraneoplastic

auxiliary to neoplasia.

paraneoplastic syndrome
a collective term for disorders arising from metabolic effects of cancer on tissues remote from the tumor; such disorders may, for example, appear as primary endocrine, hematological or neuromuscular disorders. See also pseudohyperparathyroidism.
References in periodicals archive ?
The progression of this tumour, by virtue of its natural history or perhaps the medical treatment of the cutaneous lesions, may have led to the development of ADM as a paraneoplastic phenomenon.
In addition to the paraneoplastic phenomenon, the unusual presentation of malignancies mimicking rheumatic disorders has been a clinical challenge and may be the cause of the delayed diagnosis of the main disease.
Studies commonly showed that cancer- associated DM is a paraneoplastic phenomenon.
In clinical practice, the radiologist is usually the first to raise the alarm that a paraneoplastic phenomenon is suspected, and correlation with other criteria for PNLE follows.
4] binding by TTR has also been reported as an acquired paraneoplastic phenomenon in patients with pancreatic and hepatic tumors (13,14).
Hypereosinophilia is usually referred to as a paraneoplastic phenomenon and sometimes can be attributed to factors other than the tumor per se.
Eosinophilic fasciitis as a paraneoplastic phenomenon associated with metastatic colorectal carcinoma.

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