paraneoplastic syndrome

(redirected from Paraneoplastic phenomenon)

paraneoplastic syndrome

 [par″ah-ne″o-plas´tik]
a collective term for disorders arising from metabolic effects of cancer on tissues remote from the tumor; such disorders may, for example, appear as primary endocrine, hematologic, or neuromuscular disorders.

par·a·ne·o·plas·tic syn·drome

a syndrome directly resulting from a malignant neoplasm, but not resulting from the presence of tumor cells in the affected parts.

paraneoplastic syndrome

Oncology A co-morbid condition due to the indirect–remote or 'biologic' effects of malignancy, which may be the first sign of a neoplasm or its recurrence; PSs occur in > 15% of CAs, are caused by hormones, growth factors, biological response modifiers, and other as-yet unidentified factors, and may regress with treatment of the primary tumor. See Ectopic hormone.
Paraneoplastic syndromes
GI tract, eg anorexia, vomiting, protein-losing enteropathy, liver disease
Hematologic, eg leukemoid reaction, reactive eosinophilia, peripheral 'cytoses or 'cytopenias, hemolysis, DIC, thromboembolism, thrombophlebitis migrans
Hormonal effects
Metabolic disease, eg lactic acidosis, hypertrophic pulmonary osteoarthropathy, hyperamylasemia, hyperlipidemia
Neuromuscular, eg peripheral neuropathy, myopathy, CNS, spinal cord degeneration, inflammation
Renal, eg nephrotic syndrome, uric acid nephropathy
Skin, eg bullous mucocutaneous lesions, acquired ichthyosis, acanthosis nigricans, dermatomyositis
Others, eg callus formation, hypertension, and amyloidosis

par·a·ne·o·plas·tic syn·drome

(par'ă-nē-ō-plas'tik sin'drōm)
A syndrome directly resulting from a malignant neoplasm, but not resulting from the presence of tumor cells in the affected parts.

Paraneoplastic syndrome

A set of symptoms that is associated with cancer but is not directly caused by the cancer.
Mentioned in: Thymoma

par·a·ne·o·plas·tic syn·drome

(par'ă-nē-ō-plas'tik sin'drōm)
Syndrome directly resulting from a malignant neoplasm, but not resulting from presence of tumor cells.
References in periodicals archive ?
The pathophysiology of this interesting paraneoplastic phenomenon is still not well delineated.
Hepatic panel abnormalities in the absence of hepatic metastasis, a condition known as Stauffer's syndrome, have been described as a paraneoplastic phenomenon classically in early-stage renal cell carcinoma (RCC) [5].
Neurological symptoms may also be a paraneoplastic phenomenon. In some cases, these may be the presenting complaints.
The possible underlying pathophysiologic mechanisms for IMNs following SCT are an immune reconstitution syndrome, GVHD, or a paraneoplastic phenomenon [1].
Second, the tumor was associated with unexplained hypercalcemia which has been interpreted clinically as a paraneoplastic phenomenon and led to the discovery of the tumor in conjunction with the upper abdominal symptoms.
Glucagonoma, due to oversecretion of glucagon is associated with a characteristic paraneoplastic phenomenon, called glucagonoma syndrome, which consists of specific rash known as necrolytic migratory erythema (NME), mild diabetes mellitus (DM), weight loss, normochromic normocytic anemia, glossitis, stomatitis, hypoaminoacidemia, deep vein thrombosis and depression [7].
We are reporting Leser-Trelat as a paraneoplastic phenomenon secondary to invasive ductal breast carcinoma for its rarity and the classical clinicopathological evidence.
The progression of this tumour, by virtue of its natural history or perhaps the medical treatment of the cutaneous lesions, may have led to the development of ADM as a paraneoplastic phenomenon.
Studies commonly showed that cancer- associated DM is a paraneoplastic phenomenon. However, the etiology of DM in patients with cancer is poorly understood.
According to our findings, we do not consider the sacroiliac pain of our patient as a paraneoplastic phenomenon but the direct involvement of the iliac bone by lymphoma mimicking unilateral sacroiliitis.
The rapid progression towards OMS with multidirectional eye movements and jerking body movements and ultimately coma strongly suggests a paraneoplastic phenomenon, even if standard serological screening for anti-neuronal antibodies associated with OMS remained negative.
Figurate erythema with bullous pemphigoid: a true paraneoplastic phenomenon? Clin Exp Dermatol.

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