paraneoplastic syndrome

(redirected from Paraneoplastic phenomenon)

paraneoplastic syndrome

 [par″ah-ne″o-plas´tik]
a collective term for disorders arising from metabolic effects of cancer on tissues remote from the tumor; such disorders may, for example, appear as primary endocrine, hematologic, or neuromuscular disorders.

par·a·ne·o·plas·tic syn·drome

a syndrome directly resulting from a malignant neoplasm, but not resulting from the presence of tumor cells in the affected parts.

paraneoplastic syndrome

Oncology A co-morbid condition due to the indirect–remote or 'biologic' effects of malignancy, which may be the first sign of a neoplasm or its recurrence; PSs occur in > 15% of CAs, are caused by hormones, growth factors, biological response modifiers, and other as-yet unidentified factors, and may regress with treatment of the primary tumor. See Ectopic hormone.
Paraneoplastic syndromes
GI tract, eg anorexia, vomiting, protein-losing enteropathy, liver disease
Hematologic, eg leukemoid reaction, reactive eosinophilia, peripheral 'cytoses or 'cytopenias, hemolysis, DIC, thromboembolism, thrombophlebitis migrans
Hormonal effects
Metabolic disease, eg lactic acidosis, hypertrophic pulmonary osteoarthropathy, hyperamylasemia, hyperlipidemia
Neuromuscular, eg peripheral neuropathy, myopathy, CNS, spinal cord degeneration, inflammation
Renal, eg nephrotic syndrome, uric acid nephropathy
Skin, eg bullous mucocutaneous lesions, acquired ichthyosis, acanthosis nigricans, dermatomyositis
Others, eg callus formation, hypertension, and amyloidosis

par·a·ne·o·plas·tic syn·drome

(par'ă-nē-ō-plas'tik sin'drōm)
A syndrome directly resulting from a malignant neoplasm, but not resulting from the presence of tumor cells in the affected parts.

Paraneoplastic syndrome

A set of symptoms that is associated with cancer but is not directly caused by the cancer.
Mentioned in: Thymoma

par·a·ne·o·plas·tic syn·drome

(par'ă-nē-ō-plas'tik sin'drōm)
Syndrome directly resulting from a malignant neoplasm, but not resulting from presence of tumor cells.

paraneoplastic

auxiliary to neoplasia.

paraneoplastic syndrome
a collective term for disorders arising from metabolic effects of cancer on tissues remote from the tumor; such disorders may, for example, appear as primary endocrine, hematological or neuromuscular disorders. See also pseudohyperparathyroidism.
References in periodicals archive ?
Glucagonoma, due to oversecretion of glucagon is associated with a characteristic paraneoplastic phenomenon, called glucagonoma syndrome, which consists of specific rash known as necrolytic migratory erythema (NME), mild diabetes mellitus (DM), weight loss, normochromic normocytic anemia, glossitis, stomatitis, hypoaminoacidemia, deep vein thrombosis and depression [7].
We are reporting Leser-Trelat as a paraneoplastic phenomenon secondary to invasive ductal breast carcinoma for its rarity and the classical clinicopathological evidence.
The progression of this tumour, by virtue of its natural history or perhaps the medical treatment of the cutaneous lesions, may have led to the development of ADM as a paraneoplastic phenomenon.
Studies commonly showed that cancer- associated DM is a paraneoplastic phenomenon.
In addition to the paraneoplastic phenomenon, the unusual presentation of malignancies mimicking rheumatic disorders has been a clinical challenge and may be the cause of the delayed diagnosis of the main disease.
8) Doege-Potter Syndrome, a paraneoplastic phenomenon may present with tumor with associated hypoglycemia due to insulin like growth factor.
On the basis of these observations, BP with FE may be regarded as a paraneoplastic phenomenon, especially in cases that are resistant to conventional immunosuppressive therapy.
In clinical practice, the radiologist is usually the first to raise the alarm that a paraneoplastic phenomenon is suspected, and correlation with other criteria for PNLE follows.
They have debated whether RS3PE is a paraneoplastic phenomenon, a disease or syndrome or with regard to the latter, an extension of polymyalgia rheumatic (PMR).
15) Otherwise, an association including a paraneoplastic phenomenon appears unlikely, because of the fact that most cases of Grover disease are not associated with malignancies.

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