Paraneoplastic limbic encephalitis | definition of paraneoplastic limbic encephalitis by Medical dictionary
paraneoplastic limbic encephalitis
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paraneoplastic limbic encephalitis Abbreviation: PNLE
A brain disorder occurring in some patients with cancer, characterized by the rapid onset of memory loss, often with temporal lobe disease, seizures, delirium, or disturbances of mood. Patients with PNLE often have antibodies against tumor antigens that also react with nerve cell antigens. In some patients the neurological disorder improves after treatment of the responsible tumor.
References in periodicals archive
Paraneoplastic limbic encephalitis
(PNLE) was first described by Corsellis et al.
These two antibodies have in common the association with idiopathic or paraneoplastic limbic encephalitis
Patients with paraneoplastic limbic encephalitis
commonly present with behavioral or mood changes that mimic those of psychiatric illnesses such as schizophrenia and bipolar disorder, which often delays diagnosis.