MALT1

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MALT1

A gene on chromosome 18q21 that encodes a protein which enhances BCL10-induced activation of NF-kappaB and is involved in nuclear export of BCL10. MALT1 binds to TRAF6, inducing TRAF6 oligomerisation and activation of its ubiquitin ligase activity; MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.

Molecular pathology
MALT1 translocation t(11;18)(q21;q21) with BIRC2 occurs in ± 50% of cytogenetically abnormal low-grade MALT lymphomas.
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4) The t(11;18)(q21;q21) chromosomal translocation, resulting in the production of a fusion protein composed of the apoptosis inhibitor API2 on chromosome 11q21 and the paracaspase MALT1 on chromosome 18q21, is the most common structural abnormality identified in the primary pulmonary MZL.