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Pregnancy-associated plasma protein A (PAPP-A) also known as Pappalysin-1 is a protein encoded by the PAPP-A gene in humans, located on human chromosome 9q33.1 [46].
The presence of PAPP-A antigen in the circulation of pregnant women was first reported in 1974 (3), but it was only recently shown that PAPP-A is a metalloproteinase of the metzincin superfamily (pappalysin-1, EC (4,5).
Pappalysin-1 (pregnancy-associated plasma protein-A).