Pappalysin-1 | definition of Pappalysin-1 by Medical dictionary
pregnancy-associated plasma protein A (redirected from Pappalysin-1)
pregnancy-associated plasma protein A Abbreviation: PAPP-A
A plasma protein that is used as a screening test between 8 and 14 weeks gestation; diminished levels of the protein suggest an increased risk for Down syndrome, intrauterine growth retardation, preeclampsia, and stillbirth.
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References in periodicals archive
Pregnancy-associated plasma protein A (PAPP-A) also known as Pappalysin-1
is a protein encoded by the PAPP-A gene in humans, located on human chromosome 9q33.1 .
The presence of PAPP-A antigen in the circulation of pregnant women was first reported in 1974 (3), but it was only recently shown that PAPP-A is a metalloproteinase of the metzincin superfamily (pappalysin-1, EC 184.108.40.206) (4,5).
Pappalysin-1 (pregnancy-associated plasma protein-A).