Panton-Valentine leukocidin


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Panton-Valentine leukocidin

A pore-forming toxin secreted by Staphylococcus aureus that has recently been associated with necrotising pneumonia. In vitro, PVL induces polymorphonuclear cell death by necrosis or by apoptosis, depending on the PVL concentration. PVL-induced apoptosis was associated with a rapid disruption of mitochondrial homeostasis and activation of caspase-9 and -3, suggesting that PVL-induced apoptosis is preferentially mediated by mitochondria.

Pan·ton-Val·en·tine leu·ko·ci·din

(pan'tŏn-val'ĕn-tīn lū'kŏ-sī'din)
A staphylococcal cytolytic toxin that can act on polymorphonuclear leukocytes.

Panton-Valentine leukocidin

a nonhemolytic toxin produced by Staphylococcus aureus which kills segmented neutrophils and macrophages.
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Molecular characterization of methicillin-resistant Panton-valentine leukocidin positive Staphylococcus aureus clones disseminating in Tunisian hospitals and in the community.
Detection of Panton-valentine leukocidin gene in Staphylococcus aureus by LightCycler PCR: clinical and epidemiological aspects.
Panton-Valentine leukocidin and staphylococcal skin infections in school children.
Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis.
Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia.
Development of a triplex real-time PCR assay for detection of Panton-Valentine leukocidin toxin genes in clinical isolates of methicillin-resistant Staphylococcus aureus.
Panton-valentine leukocidin and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities.
The watchdog encouraged better reporting of cases of Panton-Valentine Leukocidin (PVL) after it was linked to several deaths in the UK.
On the other hand, staphylococcal skin infections located on the torso are three times more likely to be Panton-Valentine leukocidin (PVL) negative than PVL positive, Dr.
The researchers also examine the role of Panton-Valentine leukocidin as a virulence factor in MRSA, S.
Community-acquired meticilin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin.
aureus clone containing the Panton-Valentine leukocidin (PVL) genes, Dr.