Paneth cell


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Paneth cell

narrow, pyramidal or columnar epithelial cell with a nucleus close to its base. Found in the fundus of the mucosal crypts in the intestine.
References in periodicals archive ?
Distorted crypt architecture is frequent, as is surface epithelial sloughing and Paneth cell metaplasia.
thetaiotaomicron has been shown to regulate the expression of endogenous protein antibiotic production of Ang4 by Paneth cells (32-34).
In the small intestine, so-called Paneth cells normally secrete antimicrobial compounds (SN: 8/26/00, p.
Long known as Paneth cells, these sentries inhabit tiny pits in the intestine called crypts.
But the researchers found that when Paneth cells are removed and replaced with two small molecules involved in cell signalling, these molecules could direct the stem cells to develop into pure populations of proliferating stem cells.
The alphadefensin family consists of 6 members, 4 of which are found in the primary granules of neutrophils (accounting for 30% of total granule protein), and 2 in the Paneth cells of the crypts of the small intestine.
by Paneth cells in the small intestine (8), by mucus-producing cells in the intestine, and in the gall bladder, biliary tract, kidney, lung, liver, and breast (9,10).
In addition, the Paneth cells (secretory cells) in the spiked-fed group were highly activated and contained a large number of secretory granules.
Methyl mercury in primates produces histologic abnormality of one intestinal cell line: Paneth cells are enlarged and packed with secretory granules (21), also specifically reported in autistic children (5).
Enterocytes: Presence versus loss of brush border, shape and height of enterocytes, intracytoplasmic vacuolation, presence of goblet cells or Paneth cells, denudation or damage of the surface enterocytes.
Although the mechanisms are not entirely clear, glucocorticoids appear to promote the growth of Paneth cells at the expense of goblet cells at the base of the intestinal crypts.
An absorptive brush border is evident, and Paneth cells may or may not be present.