SPINK1

(redirected from Pancreatic Secretory Trypsin Inhibitor)
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SPINK1

A gene on chromosome 5q32 that encodes a trypsin inhibitor secreted from pancreatic acinar cells into pancreatic juice. SPINK1 is thought to prevent trypsin-catalysed premature activation of zymogens within the pancreas and the pancreatic duct.

Molecular pathology
SPINK1 mutations are associated with hereditary pancreatitis and tropical calcific pancreatitis.
References in periodicals archive ?
Biochemistry and clinical role of trypsinogens and pancreatic secretory trypsin inhibitor.
Prediagnostic levels of anionic trypsinogen, cationic trypsinogen, and pancreatic secretory trypsin inhibitor in relation to pancreatic cancer risk.
Pancreatic secretory trypsin inhibitor stimulates the growth of rat pancreatic carcinoma cells.
Extrapancreatic origin of the pancreatic secretory trypsin inhibitor as an acute-phase reactant.
Two novel severe mutations in the pancreatic secretory trypsin inhibitor gene (SPINK1) cause familial and/or hereditary pancreatitis.
Functional analysis of recombinant pancreatic secretory trypsin inhibitor protein with amino-acid substitution.
From acute to chronic pancreatitis: the role of mutations in the pancreatic secretory trypsin inhibitor gene.
Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis.
Elevation of serum immunoreactive pancreatic secretory trypsin inhibitor contents in various malignant diseases.
Identification of novel pancreas-specific regulatory sequences in the promoter region of human pancreatic secretory trypsin inhibitor gene.
Adaptive response of the rat pancreas to dietary substrates: parallel regulation of trypsinogen and pancreatic secretory trypsin inhibitor.
Elevation of serum pancreatic secretory trypsin inhibitor (PSTI) in patients with serious injury.