SPINK1

(redirected from Pancreatic Secretory Trypsin Inhibitor)
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SPINK1

A gene on chromosome 5q32 that encodes a trypsin inhibitor secreted from pancreatic acinar cells into pancreatic juice. SPINK1 is thought to prevent trypsin-catalysed premature activation of zymogens within the pancreas and the pancreatic duct.

Molecular pathology
SPINK1 mutations are associated with hereditary pancreatitis and tropical calcific pancreatitis.
References in periodicals archive ?
Radioimmunoassay for human pancreatic secretory trypsin inhibitor: measurement of serum pancreatic secretory trypsin inhibitor in normal subjects and subjects with pancreatic diseases.
Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis.
Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis.
The multiplicity of human pancreatic secretory trypsin inhibitor.
Solution structure of a variant of human pancreatic secretory trypsin inhibitor determined by nuclear magnetic resonance spectroscopy.
Extrapancreatic origin of the pancreatic secretory trypsin inhibitor as an acute-phase reactant.
Elevation of serum pancreatic secretory trypsin inhibitor (PSTI) in patients with serious injury.
Elevated pancreatic secretory trypsin inhibitor levels during severe inflammatory disease, renal insufficiency, and after various surgical procedures.
Plasma levels of pancreatic secretory trypsin inhibitor in relation to amylase and lipase in patients with acute and chronic renal failure.