SPINK1

(redirected from Pancreatic Secretory Trypsin Inhibitor)
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SPINK1

A gene on chromosome 5q32 that encodes a trypsin inhibitor secreted from pancreatic acinar cells into pancreatic juice. SPINK1 is thought to prevent trypsin-catalysed premature activation of zymogens within the pancreas and the pancreatic duct.

Molecular pathology
SPINK1 mutations are associated with hereditary pancreatitis and tropical calcific pancreatitis.
References in periodicals archive ?
Biochemistry and clinical role of trypsinogens and pancreatic secretory trypsin inhibitor. Crit Rev Clin Lab Sci 2006;43:103-42.
Purification and identification of a binding protein for pancreatic secretory trypsin inhibitor: a novel role of the inhibitor as an antigranzyme A.
Extrapancreatic origin of the pancreatic secretory trypsin inhibitor as an acute-phase reactant.
Pancreatic secretory trypsin inhibitor is a major motogenic and protective factor in human breast milk.
Elimination of pancreatic secretory trypsin inhibitor from the circulation.
Radioimmunoassay for human pancreatic secretory trypsin inhibitor: measurement of serum pancreatic secretory trypsin inhibitor in normal subjects and subjects with pancreatic diseases.
Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis.
The multiplicity of human pancreatic secretory trypsin inhibitor. J Biochem (Tokyo) 1985;98:687-94.
Pancreatic endoproteases and pancreatic secretory trypsin inhibitor immunoreactivity in human Paneth cells.
Elevation of serum immunoreactive pancreatic secretory trypsin inhibitor contents in various malignant diseases.
Expression of pancreatic secretory trypsin inhibitor in various cancer cells.
Identification of novel pancreas-specific regulatory sequences in the promoter region of human pancreatic secretory trypsin inhibitor gene.