palmoplantar keratoderma

(redirected from Palmo-plantar keratoderma)

keratoderma

 [ker″ah-to-der´mah]
hypertrophy of the horny layer of the skin.
keratoderma blennorrha´gicum a cutaneous manifestation of reiter's disease, most often involving the palms, soles, toes, and glans penis, and characterized by development of thick keratotic coverings; the lesions resemble those of pustular psoriasis. The disorder was formerly thought to be associated with gonorrhea.
keratoderma climacte´ricum an acquired form of keratoderma that affects the palms of the hands and soles of the feet; it occurs in women about the time of menopause and may be associated with fissuring of the thickened patches.
palmoplantar keratoderma a group of mostly inherited disorders characterized by the excessive formation of keratin, localized or diffuse, on the palms and soles, sometimes with painful lesions resulting from fissuring of the skin; it may occur alone or may accompany or be part of another disease.

pal·mo·plan·tar ker·a·to·der·ma

[MIM*148600 & MIM*244850]
the occurrence of symmetric diffuse or patchy areas of hypertrophy of the horny layer of the epidermis on the palms and soles; a group of ectodermal dysplasias of considerable variety, and either autosomal dominant or recessive inheritance.

palmoplantar keratoderma

; PPK rare, inherited group of skin diseases characterized by altered keratin formation; presents variably as diffuse, focal or punctate palmar and plantar hyperkeratosis, e.g. of weight-bearing skin; severe forms are associated with constricting digital bands, leading to autoamputation; treated by regular hyperkeratosis reduction, keratolytic ointments (e.g. 5-10% salicylic acid in white soft paraffin) and oral retinoids (i.e. vitamin A-derivative) drugs

pal·mo·plan·tar ker·a·to·der·ma

(palmō-plantăr keră-tō-dĕrmă) [MIM*148600 & 244850, MIM*148600, MIM*244850, MIM*148600 &]
Symmetric diffuse or patchy areas of hypertrophy of horny layer of epidermis on the palms and soles.
References in periodicals archive ?
The term palmo-plantar keratoderma (PPK) is given to a diverse group of conditions which describe a hyperkeratosis concurrently affecting the palms and the soles of the sufferer.
Of those members of the family who develop the palmo-plantar keratoderma, they hold a 95% chance of developing an oesophageal carcinoma in later life (22).
Causes of non-mecanical hyperkeratosis * Skin Disease ** Psoriasis ** Eczema/dermatitis ** Keratoderma blennorrhagica ** Keratoderma climactericum ** Lichen planus ** Pityriasis rubra pilaris ** Palmo-plantar keratoderma (PPK) * Infection ** Tinea pedis ** Plantar warts ** Scabies ** Syphilis * Drugs ** Lithium ** Verapamil ** Bleomycin * Systematic Disease ** Hypothyroidism ** Lymphoedema * Malnutrition ** Zinc deficiency * Internal malignancies ** Idiopathic
Differential diagnosis includes epidermolysis bullosa, cystic fibrosis, glucagonoma syndrome, widespread candidiasis, pellagra, seborrheic dermatitis, hypovitaminoses, atopic dermatitis, celiac disease, and congenital periorificial and palmo-plantar keratoderma (3).
It is characterized clinically by palmo-plantar keratoderma (PPK), aggressive early onset of periodontitis, onychogryphosis, arachnodactyly, acroosteolysis and pes planus.
Key words: Aggressive periodontitis; Palmo-plantar keratoderma, Papillon Lefe'vre syndrome
Initially some researchers3,4 considered HMS a variant of Papillon Lefe'vre syndrome (PLS) on the basis of common clinical features such as palmo-plantar keratoderma (abnormal hyperkeratosis of the palms and soles) and aggressive periodontitis.
This case report illustrates 2 siblings (11 years child and 18 years adult) of a Pakistani Muslim family with HMS whose severe palmo-plantar keratoderma and periodontal disease responded well to treatment with acitretin, co-trimoxazole and topical keratolytics.
Extra oral examination revealed similar features as that of his younger brother in the form of palmo-plantar keratoderma (PPK) (Fig 9), keratosis of the dorsal surface of hands and feet (Fig 10) and erythematous keratotic psorisiform lesions on the extensor surfaces of both elbows and knees (Fig 11) (The patient started developing the above mentioned extra oral features at the age of 2-3 years), onychogry-phosis and transverse grooving of the nails (Fig 12), arachnodactyly (Fig 13) plus additional features of acro-osteolysis (Fig 14) and pes planus.
There was marked regression of the palmo-plantar keratoderma and erythematous psorisiform keratotic lesions in both siblings.
The differential diagnosis for a rash such as the one our patient had includes tinea manuum, contact dermatitis, syphilis, and palmo-plantar keratoderma (PPK).