Paget's disease of the nipple

Paget's disease of the nipple

A slowly growing cancer of a milk duct of the breast that presents as a form of ECZEMA affecting the nipple. Diagnosis is by BIOPSY and treatment is by local surgical removal. (SirJames Paget, 1814–99, English surgeon).
References in periodicals archive ?
An immunohistochemical study of the presence of c-erbB-2 protein in Paget's disease of the nipple. Histopathology.
Paget's disease of the nipple. Breast Cancer Res Treat.
The 6 patients who presented with nipple ulceration had a punch biopsy performed which confirmed the clinical suspicion of Paget's disease of the nipple. In these patients, subsequent surgery confirmed the presence of isolated DCIS.
Early lesions of dermatoses are scaly and erythematous, with possible etiologies ranging from eczema or inflammatory skin disorders, to Paget's disease of the nipple. The management implications are widely varied for this range of disorders, from topical applications to surgical interventions.
Indications for mastectomy included infiltrating carcinoma in 40 patients (48.2%), ductal carcinoma in situ in 35 patients (42.2%), 1 case (1.2%) each of lobular carcinoma, Paget's disease of the nipple, BRCA+ and high risk benign mass, and 4 patients (4.8%) with unknown indications.
Patients with Paget's disease of the nipple, usually associated with underlying breast cancer, have been studied with regard to the possible benefit of MR imaging for their optimal management.
Breast physical examination, US and mammography were normal bilaterally; MR imaging correctly depicted Paget's disease of the nipple. Before surgery the patient underwent biopsy that showed Paget's disease associated with an underlying DCIS.
Paget's disease of the nipple can be diagnosed via cytology (nipple scrapings) or histology (wedge biopsy of the nipple).
PAGET'S disease of the nipple is a very rare form of breast cancer that can be fatal if left untreated.
Glandular Paget's disease of the nipple. Histopathology 2007; 50:812-814.
Bilateral Paget's disease of the nipple: case report.
Paget's disease of the nipple without clinically and radiologically detectable breast tumor: histochemical and immunohistochemical study of 44 cases.