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FLT4A gene on chromosome 5q35.3 that encodes a tyrosine kinase receptor for vascular endothelial growth factors (VEGF) C and D, which appear to play a role in lymphangiogenesis and maintenance of the lymphatic endothelium.
FLT4 mutations cause hereditary lymphedema type IA.
1. Plasma cell leukemia.
2. Posterior cruciate ligament, see there.