The use of PVP-I for nasal decolonization has revealed promising results.
An evaluation of 763 surgical procedures in the mupirocin group and 776 surgical procedures in the PVP-I group was performed.
A recent quasi-experimental, retrospective, nonrandomized trial compared a preoperative decontamination intervention--2 percent chlorhexidine washcloths and 0.1 2 percent chlorhexidine oral rinse the night before and morning of surgery and the use of 5 percent PVP-I intra-nasally once the morning of surgery--to historical controls without a decontamination protocol to evaluate the impact on SSI rates for patients undergoing elective orthopedic procedures with hardware implantation.
However, the microbiological cultures on the second samples obtained after the PVP-I and saline pulse irrigation did not confirm the contamination and did not show any bacterial growth (Table 3).
 prospectively investigated 414 spinal surgery patients and compared wounds irrigated with PVP-I solution (3.5% concentration) to wounds irrigated with saline solution.
Regarding cytotoxic effects of PVP-I, Kaysinger et al.
PVP-I is a broad spectrum biocidal agent which is highly soluble than other iodine compounds like Tincture of iodine and Lugols solution.
PVP-I differs from iodine, in that it is less irritating to the skin and does not require iodides or alcohol to dissolve.
PVP-I being a polymeric iodophor, reacts with oxygen containing functional groups.
After an average of 5 months' treatment with PVP-I, the surface areas of the wounds were significantly smaller in 73% of patients; 28% of the wounds had completely closed and another 45% had shrunk but had not completely closed.
The results of this pilot study support findings from previous studies, including one in which the healing rate of ulcers treated with topical PVP-I was equal to those treated systemically with amoxicillin (Dermatology 2006;212[suppl.
Senior Writer Reduction in Wound Size After PVP-I Treatment Completely closed (28%) Significantly smaller (45%) No significant change (27%) Note: Based on 42 wounds in 30 patients.