PTHrP


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PTHrP

Farlex Partner Medical Dictionary © Farlex 2012

PTHrP

Abbreviation for parathyroid hormone-related peptide.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Similar to our case, their patient also showed hypercalcemia with decreased serum iPTH and elevated PTHrP levels.
Interaction with cognate ligands of PTH1R, PTH and PTHrP, or biologically active peptide fragments, such as PTH(1-34), results in activation of Gas and Gaq with consequent stimulation of adenylate cyclase and phospholipase C (PLC) [19, 20].
Since, BDE with short stature seen in patients with PTHLH mutations, encoding PTHrP, (95,96), this point could be argued.
In bovine chromaffin cells exposed to stress, IL-6 leads to activation of ERK 1/2 and STAT3 pathways and consequently to increased activity of tyrosine hydroxylase (TH), a rate-limiting enzyme in catecholamine synthesis, and to upregulation of downstream targets including secreted neuropeptides galanin, PTH-related peptide (PTHrP), G-protein-coupled receptor (GPR), stanniocalcin-1 (STC1), and hypoxia-inducible factor 1a (HIF-1a) [85].
Workup now revealed the following: serum intact PTH: 7pg/mL (15-65 pg/mL), PTHrP: 30pmol/L (<2.0 pmol/L), 1,25-hydroxyvitamin D (calcitriol): 76pg/ml (18-64 pg/mL), 25-hydroxyvitamin D levels: <4ng/mL (20-50 ng/mL), and phosphorus level: 1.8mg/dl (2.5-4.5 mg/dL).
Typically, this is mediated by osteolytic metastases or secretion of parathyroid hormone related peptide (PTHrP).
At the time of admission, his serum parathyroid hormone-related protein (PTHrp) was significantly elevated (241pg/ml; reference value < 57).
Another recent study showed that TSC1 knockout, associated with hyperactivation of TORC-1, provokes an OA-related phenotype in cartilage, possibly connected to the downregulation of two receptors involved in chondrocyte proliferation and differentiation: the fibroblast growth factor receptor 3 (FGFR-3) and parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor (PPR) [99].
Yu, "Parathyroid hormone-related peptide (PTHrP): prokaryotic expression, purification, and preparation of a polyclonal antibody," Genetics and Molecular Research, vol.
Overall, the most prevalent cause of malignancy related hypercalcemia is ectopic production of a hormone called Parathyroid Hormone related Protein (PTHrP) which exerts similar effects to PTH (parathyroid hormone) including increased osteoclastic activity with resulting bone resorption, augmented reabsorption of calcium from kidneys, and increased renal phosphate excretion [2].
Hypercalcemia in patients with pregnancy-induced gigantomastia has been attributed to the excessive production of parathyroid hormone-related protein (PTHrP) by the (hypertrophied) breasts (12).
Multiplex PCR-based detection of circulating tumor cells in lung cancer patients using CK19, PTHrP, and LUNX specific primers.