PTEN


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Related to PTEN: p53, AKT, PI3K

PTEN

A gene on chromosome 10q23.3 which encodes PTEN (phosphatase and tensin homolog), a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase protein, which acts as a tumour suppressor by negatively regulating the AKT/PKB-signalling pathway.
References in periodicals archive ?
In contrast, patients with high PTEN expression showed a longer survival time, compared with patients with low PTEN expression (42.
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumorsuppressorgene in mice.
Finally, the antitumor activity was exploited in nude mice xenograft models with PTEN deficient Mahlavu cell lines.
The DNA damage activated PTEN linked the crosstalk between DNA damage and autophagy.
PTEN mutations have been detected in both atypical hyperplasias associated with the development of adenocarcinoma and those that did not progress to carcinoma.
PTEN cytoplasmic and nuclear staining were strong and diffuse in stromal and endothelial cells, as well as islets of Langerhans (Figure 1) in adjacent normal pancreatic tissue, and served as internal control; however, staining in PanNETs was highly variable.
Alteration of PTEN may upregulate NDRG1 expression, which plays an important role in the process leading to endometrial carcinogenesis.
The membranes were probed against PTEN (Santa Cruz, USA), or cleaved caspase-3 (Cell Signaling Technology, USA), and reprobed against GAPDH (Santa Cruz) as a loading control.
Immunohistochemical staining for PTEN was performed on 4-[micro]m unstained sections from the tissue microarray blocks by using a mouse monoclonal antibody against PTEN (6H2.
This protects the PTEN from damage when exposed to UV radiation.