PTEN


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Related to PTEN: p53, AKT, PI3K

PTEN

A gene on chromosome 10q23.3 which encodes PTEN (phosphatase and tensin homolog), a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase protein, which acts as a tumour suppressor by negatively regulating the AKT/PKB-signalling pathway.
References in periodicals archive ?
PTEN mutation located only outside exons 5, 6 and 7 is an independent predictor of favorable survival in endometrial carcinomas.
To confirm whether PTEN is a direct target of miR-106b-5p, we cloned the putative miR-106b-5p binding site on PTEN 3'-UTR or its mutational sequences into luciferase reporter plasmid and cotransfected it with miR-106b-5p mimics into HUVEC [Figure 2]a.
It has been reported that miR-21 affects the PI3K/Akt pathway through the expression of PTEN [49], but this effect has not been investigated in c-[kit.
Correlation of Loss of PTEN Expression With Clinicopathologic Features and Other Molecular Markers
PTEN expression was negatively correlated with lymph node metastasis, histological type, clinical stage, and chemosensitivity ( P = 0.
The observations reported in the 1998 article contributed to the understanding of the cellular functions of PTEN and the severity of the consequences associated with PTEN loss.
Conclusion: The results indicated that Lanatoside C could be contemplated in liver cancer therapeutics, particularly in PTEN deficient tumors.
Conclusion: Loss of phophotase and tensin homologue expression was seen in a significant number of well differentiated endometrial adenocarcinomas and complex hyperplasias with atypia suggesting loss of PTEN expression as an early event in endometrial carcinogenesis.
PanNETs have been shown to express hormone receptors (6,21-23) and there is some evidence that PTEN and hormone receptors may be functionally linked.