KPNB1

(redirected from PTAC97)

KPNB1

A gene on chromosome 17q21.32 that encodes a beta subunit of karyopherin which imports proteins into the nucleus, either alone or in association with an adaptor protein (e.g., an alpha importin subunit).
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After biochemical purification of the cytosolic extract, we isolated a stable complex called the nuclear pore-targeting complex (PTAC) containing the NLS-substrate to target the nuclear pore and found that the complex contains two essential components, a 58-kDa protein called PTAC58 and a 97-kDa protein called PTAC97. (20, 21) Several groups independently and almost simultaneously identified these two types of NTRs, and named the molecules importin [alpha] or karyopherin [alpha] for PTAC58 and importin [beta] or karyopherin [beta] for PTAC97.