For acute lung injury, 7 DNBs (Psmb5, Psma1, Psmd13, Psmc3
, Psmd4, Psme4, and Psma7) are observed in the pathways of regulating by proteasome mediated degradation, which played a key role in regulating many processes of cellular biology [29, 30].
Proteasomal components appear to be equally susceptible to age-dependent decline, with documentation of a downregulation of transcripts encoding for 20S proteasome subunits (Psma6, Psmb1, Psmb2, Psmb4, and Psmb5), ATPase (Psmc2, Psmc3
, and Psmc5), as well as the non-ATPase subunits of the 19S regulator (Psmd4, Psmd8, Psmd9, and Psmd12) [3, 97] (Table 1).
The connectivity degree of certain genes exceeded 20, including DHX15, NDUFS3, PSMC6, UBE2C, EIF4G1, DHX9, PSMC3
, and HNRNPA2B1 in the upregulated PPI network, and MAPK1, IL6, FN1, MAPK14, STAT3, and VWF in the downregulated PPI network (Table 1).
interacting protein (PSMC3IP) 0.0006 5.23 2131936 ATPase family, AAA domain containing 3B 0.001 4.55 (ATAD3B) 1683660 Eukaryotic translation initiation factor 0.0016 4.27 3, subunit H (EIF3H) 3309468 Hypothetical protein MGC12982 (MGC12982) 0.0006 4.09 1697363 Chromosome 20 open reading frame 27 0.0003 4.15 (C20ORF27) ILMN Gene Known cellular function (Ref.) Role in HCC-R ID no.